Figure 2– Distribution of ultraconserved elements (UCEs) and
their mutation impact scores (CADD scores). (A) Karyotype plot
of the chicken genome with the distribution of UCEs (black bars) and
density of UCEs (green peaks). (B) Karyotype plot of chicken
chromosome 1 showing the distribution of UCE-dense regions. Green peaks
above the 1% horizontal line are significantly enriched for UCEs
(p<0.01). At the bottom of Panel B, zoomed in at a single UCE
and its 2000bp flanking regions (i.e., UCE2729), the CADD scores of
every possible substitution at each site. The UCE is shown in blue. The
CADD scores in flanking regions are shown in red. Distribution of all
CADD scores for (C) the entire chromosome 1 of the chicken
genome, and (D) 620 UCEs in chromosome 1 and their 2000bp
flanking regions. (E) The CADD score distribution of the
flanking regions and the UCEs within the six pink pigeon genomes.
(F) SNP frequency at flanking regions and the UCEs. (See main
text for test results).