Author Contributions
Cock van Oosterhout and Samuel Speak conceived the study; Samuel Speak and Chiara Bortoluzzi developed the CADD analysis methods; Samuel Speak developed the LoadLift Snakemake and analysed the genomic data; Thomas Birley and Hernán Morales conducted the SLIM simulations; Chiara Bortoluzzi, Matthew Clark, Lawrence Percival-Alwyn, Hernán Morales and Cock van Oosterhout supervised the study; Matthew Clark and Lawrence Percival-Alwyn contributed to DNA sequencing; Samuel Speak, Hernán Morales and Cock van Oosterhout wrote the paper; all authors contributed to the manuscript and approved.