Abstract
Regulatory T (Treg) cells play a crucial role in immune tolerance, and
numerous studies have focused on the molecular mechanisms of CD4+ Treg
cells, whereas the role and relevant mechanisms of CD8+ Treg cells
remain unclear. Ly49 is located at murine NK and T cells, and plays a
similar role to human KIRs in regulation of immune response. In this
paper, we have explored the effect of AIM2 deficiency on the homeostasis
of CD8+Ly49+ regulatory T (Treg) cells in AIM2 knockout (KO) mouse
model. We have performed KLH immunization model for AIM2 KO mice and
found enhanced function of suppressive CD8+ Treg cells in the absence of
AIM2, indicating AIM2 dampens the homeostasis of murine inhibitory CD8+
Treg cells.