Patients’ characteristics (Tables 1 and S1)
Median age was 70 years, ranging from 31 to 95 years with a predominance of male (70%). The histological subtypes were: 75% diffuse large B cell lymphoma (DLBCL, n=70), 14% Burkitt lymphoma (BL, n=13), 8% high-grade B-cell lymphoma (HGBCL, n=8), and the remaining 3% were categorized in other subtypes. The majority of patients were diagnosed at advanced stage III/IV (n=88, 93%) were high risk based on the international prognostic index (IPI) score (n=70, 75%). A bulk defined as tumor size larger than 10 cm along the longest axis was present in a quarter of patients. Extranodal disease was present in the majority of patients (n=74, 80%), including central nervous system (CNS) and bone marrow involvement in 13 and 23 patients, respectively. Despite most patients having a good performance status score of 0-1 (n=59, 63%), a significant proportion displayed a Charleston comorbidity index (CCI) of more than 8 points (n=23, 25%). It is noteworthy that 33% of patients (n=31) exhibited abnormal glomerular filtration rate (GFR) values. The primary treatment approach utilized for most patients involved anthracycline-containing regimens (n=66, 72%) (Table S1).