Data collection
Clinical data were extracted from electronic medical record system of the HUG, anonymized using a study-specific patient identifier and collected in electronic certified clinical database management system software (REDCap™), an application compliant with the requirements of the Swiss clinical trial requirements. De-identified data were analyzed and stored following Swiss legal requirements for data protection using ISO 9001/2008 standards. Health related personal data were accessible only by investigators. We used Cairo and Bishop criteria to define laboratory TLS (LTLS) or clinical TLS (CTLS). LTLS involved 25% changes with baseline or upper normal value at two separate occasions (between three days before and seven days after treatment onset) of uric acid, potassium, phosphorous and calcium. CTLS was defined as serum creatinine increasing 1.5 times the upper normal values and/or seizure and/or cardiac arrhythmia [18]. The Swiss Group for Clinical Cancer Research (SAKK) provided data from the Swiss BL cohort. Comparative clinical dataset from CALGB 50303 study were available through the NCI platform.