Comparison of the pathogen distribution and mortality among
AYAs, Children and Adult
Among the 363 positive samples, the proportion of gram-negative bacteria
(GNB) was 66.8%. According to our data, the main pathogenic bacteria in
the BSIs at our center were GNB. We compared the pathogen distribution
(Fig.2A) and summarized several common bacteria among the three groups
(Table 2). AYAs patients were similar to adults in the etiology of BSIs
and had a significant difference from children. Specifically, GNB
occurred more frequently in AYAs and adults (78.3% vs. 72.7%), with
Escherichia coli being the single most common organism responsible for
BSIs in AYAs and adult cases (33.9% vs. 38.2%), whereas other isolated
GNB organisms in AYAs included K. pneumoniae (22.8%) and P. aeruginosa
(6.8%). In the pediatric population, gram-positive coagulase-negative
Staphylococcus (CoNS) was the leading organism associated with BSIs
(27.4%), whereas K. pseudomonas was the most common GNB organism
isolated from children (16.4%). Meanwhile, 26 patients experienced IFI,
giving an incidence of 10 (5.6%), 5 (6.8%), and 11 (10%) in the
children, AYAS, and adult groups, respectively. We further compared the
mortality rates among the groups (Fig. 2B). There was no significant
difference between AYAs and adults (GNB:14.2% vs. 21.3%, P=0.176;
GPB:20.7% vs. 21.1%, P=0.976; IFI:30% vs. 36.4%, P=0.757).