Fig. 6 Schematic representation of the synergistic antimicrobial
mechanism of R12-AgNPs with H2O2.
Biocompatibility evaluation of R12-AgNPs
The biocompatibility of nanoparticles is a critical factor in
determining their potential biomedical applications. Therefore, it is
essential to evaluate the biocompatibility of R12-AgNPs. The
cytotoxicity of R12-AgNPs was assessed in vitro using mouse fibroblast
(L929). As shown in Fig. 7, the cell viability remained at 92.39% when
the concentration of R12-AgNPs was below 10 µg/mL. Even a higher
concentration of 75 µg/mL, a cell viability of 80% was achieved. The
results indicate that R12-AgNPs had low cytotoxicity and their potential
suitability as a material for biomedical applications. The favorable
biocompatibility of R12-AgNPs is an important finding, as it opens the
door to various biomedical applications where these nanoparticles can be
utilized without causing significant harm to living cells.