In this work, we have proposed and experimentally demonstrated a true full-duplex IO (TFD-IO) for high-speed high-density interfaces. The proposed TFD-IO can be used as an independent module that converts a unidirectional IO/interconnect to a fully bidirectional IO/interconnect, to ideally double the throughput of the high-speed interface. The TFD-IO uses a correlation-based technique to cancel the self-interference (SI) adaptively in the background. The signals transmitted from the near-end and the far-end can use independent baud-rates and signaling schemes in a TFD-IO. A proof-of-concept design of the TFD-IO module has been fabricated in a 65 nm CMOS technology, and demonstrated with bidirectional throughputs of up to 12.8\,Gb/s.