2.3 H&E staining and immunofluorescence
The acquired mice skin tissues were fixed in 4% paraformaldehyde solution, and paraffin blocks were treated and stained by hematoxylin/eosin (HE). For immunofluorescence staining (IFC), main steps were performed as described previously [10]. All sections were examined with laser confocal microsopes (AOSVI, M303-HK830).