Monkeypox is a viral disease with skin rashes and symptoms similar to smallpox. Evidence suggests it can be sexually transmitted. This review focuses on the current understanding of sexual transmission, clinical manifestations, and roles of healthcare providers such as dentists and clinicians. Limited data exists on sexual transmission, making it less important for healthcare providers to consider it in patient management. Dentists and clinicians should be aware of the clinical manifestations and be vigilant for signs in patients with recent sexual contact. This review highlights the importance of ongoing surveillance and research into the sexual transmission of monkeypox and the role of healthcare providers in its management.