Figure 1 : Interleukins involved in substance abuse. Various members of the interleukin family and their receptors are shown. Possible receptor-ligand interactions that initiate downstream signaling are also indicated. IL-1R1, type I IL-1 receptor; IL-1R2, type I IL-2 receptor; IL-2RA, IL-2-receptor alpha chain; IL-2RB, IL-2 receptor subunit beta; IL-2RG, IL-2 receptor subunit gamma; IL4R, IL-4-receptor; IL-6RA, IL-6-receptor alpha chain; IL-6RB, IL-6 receptor subunit beta; IL-8RA, IL-8-receptor alpha chain; IL-8RB, IL-8 receptor subunit beta; IL-10RA, IL-10-receptor alpha chain; IL-10RB, IL-10 receptor subunit beta; IL-15RA, IL-15-receptor alpha chain; IL-17RA, IL-14-receptor alpha chain; IL-18R1, type I IL-18 receptor; IL-23R, IL-23-receptor