Drug abuse is a universal phenomenon that happens across the world. And
the neurotoxicity caused by drug abuse in the central nervous system has
been extensively studied during the last decade. More recently, the role
of drugs causing neuroinflammation, which would subsequently affect
dopaminergic neurotoxicity, has aroused wide attention. This paper aims
to present a literature review of the studies on the role of the
interleukin family in substance-dependent neuroinflammation. Currently,
the most studied cytokines in the interleukin family in the drug field
are IL-1 and IL-6. In addition, based on the previous literature on
changes in interleukin in neuroinflammation induced by different drugs,
this paper identifies neuroinflammation-related diseases caused by
interleukin families, and summarizes recent advances in the dynamics,
mechanisms, immunomodulatory and anti-inflammatory effects that are
related to the pathogenesis of these diseases. In conclusion, this
review elucidates substance-dependent neurotoxicity from the perspective
of interleukin alterations.