Drug induced QT prolongation Drug induced QT prolongation Physiologically induced QT prolongation Physiologically induced QT prolongation
Class Drug Category Cause
Antiandrogens
Apalutamide AR inhibitors CYP inhibitors Degarelix Enzalutamide Finasteride Flutamide GnRH agonists and antagonists
Cardiac
Bradycardia Heart failure Hypertension Myocardial infarction Ventricular hypertrophy
Antiarrhythmics
Amiodarone Disopyramide Dofetilide Ibutilide Procainamide Quinidine Sotalol
Electrolytes
Hypocalcemia Hypokalemia, Hypomagnesemia
Antibiotics
Clarithromycin Erythromycin Grepafloxacin Levofloxacin Moxifloxacin Pentamidine Sparfloxacin
Endocrine
Cushing’s Diabetes mellitus Hyperthyroidism
Antidepressants
Amitriptyline Desipramine Doxepin Fluoxetine Imipramine Maprotiline Sertraline
Genetic
Congenital adrenal hyperplasia Kalman syndrome Klinefelter syndrome LQTS: LQT1 (KCNQ1), LQT2 (KCNH2) and LQT3 (SCN5A) Prader-Willi syndrome
Antihistamine
Astemizole Terfenadine
Hepatic
Cirrhosis
Antimalarial
Chloroquine Halofantrine
Patient factors
Advanced age Female gender High body mass index High cholesterol Low testosterone
Antipsychotic
Chlorpromazine Citalopram Clozapine Droperidol Haloperidol Mesoridazine Pimozide Risperidone Sertindole Thioridazine Ziprasidone
Renal
Chronic renal disfunction
GI drugs
Cisapride Domperidone
Trauma
Testicular torsion
Opiate agonists
Methadone
Other
Arsenic trioxide Bepridil DECA Diuretics Probucol