Anti-CD28 improved mortality of CLP-induced sepsis mice
Therefore, animal models were designed to verify effects of CD28 on ratio of Th17 to Treg in septic mice. With administrated anti-CD28 functional antibody (5 mg/kg) after CLP, both 7-days survival rate (Fig5.a) and clinical scores (Fig5.b) of mice were improved obviously. The white pulp nodule in septic mice’s spleen was disordered, and the boundary between white pulp and red pulp was blurred (Fig5. c). After detur CD28 antibody, the disorder of white pulp nodule and histopathological score (Fig5. d) were alleviated while spleen index (Fig5. e) were aggrandized.