Anti-CD28 Ab amended Th17/Treg imbalance in sepsis mice
As Th17 and Treg variation in sepsis patients, Th17 and Treg variation
in CLP induced sepsis mice had similar trends. Treg and Th17 in spleen
of CLP mice were decreased obviously (Figure 6a, b). After treated with
CD28 antibody, the extent of Treg and Th17’ increase amplitude was
lower, as well as the proportion of Th17/Treg (Figure 6c, d, e). Serum
levels of IL-6,TNF-α and IL-17A were increased significantly in CLP
mice, while the level of IL-10 was increased slightly. Meanwhile, such
trends were reversed by administrated with CD28 functional antibody
(Fig6. F, G, H and I).