Fig.5 A , the Kaplan-Meier survival analysis 7 d after CLP in isotype treat and CD28 functional antibody mice. The Kaplan-Meier survival curves were compared by the log-rank test. Line-graphs show mean and standard error(n=10 mice per group). B , Mice’s Murine Sepsis Score (MSS) over time that were administered 5 mg/kg CD28 functional antibody (n = 5). C , Histology of spleen (Original magnification: 200×), Scale bar, 100 mm. D , Spleen histopathological score(n=5), the values presented are mean ±SEM, n=6.E , spleen index(n=5). The values presented are mean ±SEM, *p<0.05, ** p<0.01, ***p<0.001, The data are representative of 3 independent experiments.