Statistics
All analyses were done using SPSS, version 22.0 (IBM Corp. Armonk, NY, USA), MedCalc Statistical Software, version 19.5 (MedCalc Software Ltd, Ostend, Belgium) and GraphPad Prism 8.0(GraphPad Software, San Diego, CA, USA). Continuous variables were reported as mean ± SD or as median (IQR) after testing their normal distribution using the Kolmogorov-Smirnov test. For two-group comparisons, the independent samples t-test was used for normally distributed data, and the Mann-Whitney test was used for non-normally distributed data. For the comparison of multi-group, one-way analysis of variance and the Kruskal-Wallis test was used to analyze normally and non-normally distributed data. Categorical data are summarized using number (percentage), and were compared using the chi-square or Fisher’s exact test. Spearman’s rank correlation was applied to determine the correlation between variables. The area under the receiver operating characteristic (ROC) curve was calculated to evaluate the tested parameters’ diagnostic and prognostic value and a value of P <0.05 was considered statistically significant.