Animals
Male C57BL/6 mice aged 6–8 weeks and weighing 20-25g were used and bred
carefully in the Changhai Hospital Animal Laboratory Centre under the
ethical guidelines of the National Institutes of Health on Animal Care.
Mice were raised in specific pathogen-free cages and maintained at
temperatures between 20 and 25 °C and relative humidity of 50–70%. The
experimental protocols were approved by the Animal Care and Use
Committee of Navy Medical University, Shanghai.