CD28 and ligands expression levels in sepsis patients
The expression level of CD28 of peripheral blood CD4+T lymphocytes was obviously increased in sepsis patients [compared with healthy volunteers, 84.21 (73.24-95.05) vs 17.05 (12.40-22.10), p<0.001, Figure 4]. Meanwhile neither CD28, CTLA-4 nor their ligands CD80, CD86 expression levels was without significant in all sepsis patients. The Th17/Treg ratio was positively correlated with the expression level of CD28 in CD4+ T lymphocytes (r2 =0.2615, P<0.01, Figure 4c).