Anti-CD28 improved mortality of CLP-induced sepsis mice
Therefore, animal models were designed to verify effects of CD28 on
ratio of Th17 to Treg in septic mice. With administrated anti-CD28
functional antibody (5 mg/kg) after CLP, both 7-days survival rate
(Fig5.a) and clinical scores (Fig5.b) of mice were improved obviously.
The white pulp nodule in septic mice’s spleen was disordered, and the
boundary between white pulp and red pulp was blurred (Fig5. c). After
detur CD28 antibody, the disorder of white pulp nodule and
histopathological score (Fig5. d) were alleviated while spleen index
(Fig5. e) were aggrandized.