Diagnostic Value of Monocyte, Eosinophil, Platelet-Lymphocyte Ratio And
Monocyte Lymphocyte Ratio In Previously Healthy Covid-19 Patients
Abstract
Aim: In this study we aimed to investigate diagnostic usefullness and
optimal cut-off values of monocyte, mean platelet volume (MPV),
eosinophil, neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio
(PLR), monocyte lymphocye ratio (MLR), red blood cell distribution width
(RDW) in laboratory confirmed Covid-19 cases with and without pneumonia
who were totally healthy before being infected with Covid-19. Materials
and Methods: Data of a total 10000 patients who were admitted to
hospital with complaints apropriate with Covid-19 in six months
(March–Agust 2020) interval and underwent SARS-CoV-2 Polymerase Chain
Reaction (PCR) investigated. Out of 10000 patients we included only
previosly healthy 174 patients with Covid-19 pneumonia, 144 SARS-CoV-2
positive but no pneumonia and SARS-CoV-2 PCR negative 156 healthy
controls. The laboratory results and demographic findings were collected
from patient files retrospectively before undergiong treatment for
Covid-19. Results: We found wbc levels lower in Covid-19 patients with
pneumonia (p <0.001 vs healthy), as well as neutrophil (p
<0.001 vs healthy), Monocyte (p <0.001 vs healthy
and Covid-19 without pneumonia), Eosinophil (p <0.001 vs
healthy and Covid-19 without pneumonia) and Platelet count (p
<0.001 vs healthy). MLR remained higher in patients without
pneumonia (p <0.001 vs Covid-19 with pneumonia and healthy
controls) as well as PLR (p <0.001 versus Healthy).
Conclusion: In the light of the obtained results, decrease in wbc,
neutrophil, monocyte and eosinophil levels support the diagnosis of
Covid-19 pneumonia on the other hand increase in MLR and PLR may
indicate Covid-19 without pneumonia. Keywords: Covid-19 pneumonia,
esoinophil, monocyte