A pre-clinical model combined cryopreservation technique with precision-cut slice culture method to assess in vitro drug response of hepatocellular carcinoma
Yuan Zhang1,2,3, Zhen-yu Wang1,4, Hong-shu Jing1,4, Hong-dan Zhang6, He-xin Yan1,5, Jian-xia Fan2,3*, Bo Zhai1,4*
1Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Chinaï¼›
2International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;
3Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China
4State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai;
5Department of Anesthesiology and Critical Care Medicine, Renji Hospital, Jiao Tong University School of Medicine, Shanghai, China.
6Celliver Biotechnology Co. Ltd, Shanghai, China.
Correspondence to:
*Bo Zhai, Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, China.
E-mail: zhaiboshi@sina.com; Postal address: 200127.
*Jian-xia Fan, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
E-mail: fanjianxia122@126.com; Postal address: 200030.
*Contributed equally