Abstract
A thirty-eight year-old male presented with a seven-week history of persistent fever accompanied by recurrent night sweats, chills, arthralgias, headache, and chest tightness. Initial laboratory testing showed non-specific elevation of inflammatory markers, but was otherwise unremarkable. A palmar rash developed one week later, prompting testing for syphilis. Fluorescent treponemal antibody absorption (FTA-ABS) and rapid plasma reagin (RPR) tests were both positive. Penicillin G was administered and the patient recovered uneventfully. Our case emphasizes the need for increased syphilis screening to ensure proper diagnosis and prompt treatment.