Table 1: Overview of the reviewed sources relating to appropriate therapy in CS
Authors Publication Year Location Study design Cohort Size Findings relevant to this section
Ellenbogen et al.(1) 2006 North America Prospective 458 “Appropriate therapy” is an effective proxy of SCD in non-ischaemic cardiomyopathies.
Azoulay et al.(5)
2020
Global
Retrospective
464
Statistically significant factors in predicting appropriate therapy are: Young age, male sex, low LVEF, ventricular pacing, complete heart block. Statistically non-significant factors in predicting appropriate therapy are: LBBB/RBBB, positive CMR & syncope
Taha et al.(6) 2022 Global Retrospective 530 (Includes several non-predictors of appropriate therapy, please see main text)
Schuller et al.(7) 2012 North America Retrospective 112 Higher rates of appropriate therapy in those with RV dysfunction.
Halawa et al.(8) 2020 Global Mixed prospective & retrospective 585 Rates of appropriate therapy higher in those with AVB.
Franke et al.(9) 2020 Global Mixed prospective & retrospective 1247 Higher rates of appropriate therapy in those whom ICD was implanted for secondary prevention.
Mathijssen et al.(10) 2022 Netherlands Retrospective 105 Higher rates of appropriate ICD therapy in male sex, 2nd/3rd degree AVB, prior VA, and presence of LGE on CMR – most strongly with LGE in the area of RV.
Kron et al.(11) 2013 North America Retrospective 33 Young age and reduced LVEF predict appropriate ICD therapy.