FIGURE LEGENDS
Figure 1. Evolution of the genomic landscape in two patients of
our cohort. For each patient, we show the variant allele frequency
(VAF, left Y axis) of each somatic mutation identified by clinical
monitoring with the NGS Oncomine Myeloid Research Assay. Each mutation
is labelled according to the left legend shown above the graphs. On the
X axis we report the date of testing. Response to treatment was
monitored in the BM of the patient by immunophenotype of the myeloid
blasts (% blasts, right Y axis). A. Patient ID5. In panel A,
we also show the percentage of donor cells in the peripheral blood (%
donor PB cells, right Y axis), following allogeneic BM transplantation
(post Allo-TMB). The small black arrow indicates the timing of induction
chemotherapy. B. Patient ID7. The first black arrow shows the
timing of induction therapy and the second of re-induction therapy.
Beg., beginning.