Introduction: Migraine is one of the most common complaints and is debilitating as it affects the quality of life. Triptans are considered effective and are frequently prescribed by primary physicians and neurologists. Renal infarction is rare side effect of triptans that can be misdiagnosed if not considered in patients using them (2,3). Clinical presentation of renal infarction can be misleading in some cases. We present a case of middle-aged lady, who was diagnosed with renal infarction after long-standing use of Zolmitriptan. Although, renal infarction is a rare side effect after triptans use, but it should be considered in patients who use these medications regularly.