3.1-First Case:
Biochemical workup revealed a white blood count (WBC) of
13,000/mm3 with 80% neutrophils. C-reactive protein
(CRP) was elevated with a value of 17.7 mg/dL. Liver enzymes and the
remainder of the blood tests were within normal range. Stool culture
using Cefsulodin-Irgasan-Novobiocin (CIN) selective agar medium produced
characteristic colony morphology that grew Yersinia
enterocolitica . He had a serum iron of 180 U g/dL with a ferritin
level of 1,250 ng/mL. Total iron-binding capacity (TIBC) was 320U g/L with a transferrin saturation (TSAT) of 57%., pointing to a
state of iron-overload. The patient underwent HFE genetic testing
and was homozygous for C282Y, indicating a diagnosis of HH. Magnetic
resonance imaging (MRI) of the abdomen subsequently revealed reduced
signal intensity of the liver, corroborating a diagnosis of liver
hemochromatosis.