Diseases Wnt Trend Activated Cells Proinflammatory Cytokines Signaling Pathway Pathophysiology phenotype
Sepsis Increased Macropages IL-1β/IL-6/ IL-8/MIP-1b Wnt5a/FZD5/ CaMKII Inflammation
Asthma Increased Airway SMCs TGF-β1 Wnt5a/JNK Airway remodeling/ Hyperresponsiveness/ Inflammation
COPD Increased Alveolar epithelial cells IL-6/IL-8 Wnt5a/JNK1 Emphysema/ impaired tissue repair
Tuberculosis Increased Macrophages IL-6/IL-12/ TNF-α/IL-1β FOXO1/Wnt5a TLR/NF-κB Immune regulation
Rheumatoid Arthritis Increased Macrophages/ Synovial Fibroblasts IL-6/IL-8/ IL-15 Wnt5a/FZD5 Inflammation
Atherosclerosis Increased Macrophages/ Endothelial cells/SMCs COX-2/MCP-1/MMP-2/MMP-9 Wnt5a/Ror2 MAPK/NF-κB USP17/RAC1 mTORC1-NPC1/NPC2 Calcification of vascular, endothelial cells and SMCs / Inflammation/LDL Oxidization
Psoriasis Vulgaris Increased Epidermal Keratinocytes Non-specific Wnt5a/FZD5 Inflammation