Sepsis
|
Increased
|
Macropages
|
IL-1β/IL-6/
IL-8/MIP-1b
|
Wnt5a/FZD5/
CaMKII
|
Inflammation
|
Asthma |
Increased |
Airway SMCs |
TGF-β1 |
Wnt5a/JNK |
Airway
remodeling/ Hyperresponsiveness/ Inflammation |
COPD |
Increased |
Alveolar epithelial cells |
IL-6/IL-8 |
Wnt5a/JNK1 |
Emphysema/ impaired tissue repair |
Tuberculosis
|
Increased
|
Macrophages
|
IL-6/IL-12/
TNF-α/IL-1β
|
FOXO1/Wnt5a
TLR/NF-κB
|
Immune regulation
|
Rheumatoid Arthritis
|
Increased
|
Macrophages/
Synovial Fibroblasts
|
IL-6/IL-8/
IL-15
|
Wnt5a/FZD5
|
Inflammation
|
Atherosclerosis
|
Increased
|
Macrophages/ Endothelial cells/SMCs
|
COX-2/MCP-1/MMP-2/MMP-9
|
Wnt5a/Ror2
MAPK/NF-κB
USP17/RAC1
mTORC1-NPC1/NPC2
|
Calcification of vascular, endothelial cells and SMCs / Inflammation/LDL
Oxidization
|
Psoriasis Vulgaris |
Increased |
Epidermal Keratinocytes |
Non-specific |
Wnt5a/FZD5 |
Inflammation |