Reference:
1. Rao TP, Kuhl M. An updated overview on Wnt signaling pathways: a
prelude for more. Circulation research. 2010;106(12):1798-1806.
2. Teo JL, Kahn M. The Wnt signaling pathway in cellular proliferation
and differentiation: A tale of two coactivators. Advanced drug delivery
reviews. 2010;62(12):1149-1155.
3. Vandenberg AL, Sassoon DA. Non-canonical Wnt signaling regulates cell
polarity in female reproductive tract development via van gogh-like 2.
Development (Cambridge, England). 2009;136(9):1559-1570.
4. Kimura-Yoshida C, Nakano H, Okamura D, Nakao K, Yonemura S, Belo JA,
Aizawa S, Matsui Y, Matsuo I, Less S. Canonical Wnt signaling and its
antagonist regulate anterior-posterior axis polarization by guiding cell
migration in mouse visceral endoderm. Developmental cell.
2005;9(5):639-650.
5. Kim J, Kim J, Kim DW, Ha Y, Ihm MH, Kim H, Song K, Lee I. Wnt5a
induces endothelial inflammation via beta-catenin-independent signaling.
Journal of immunology (Baltimore, Md : 1950). 2010;185(2):1274-1282.
6. Ljungberg JK, Kling JC, Tran TT, Blumenthal A. Functions of the WNT
Signaling Network in Shaping Host Responses to Infection. Front Immunol.
2019; 10:2521.
7. Pashirzad M, Shafiee M, Rahmani F, Behnam-Rassouli R, Hoseinkhani F,
Ryzhikov M, Binabaj MM, Parizadeh MR, Avan A, Hassanian SM. Role of
Wnt5a in the Pathogenesis of Inflammatory Diseases. Journal of cellular
physiology. 2017;232(7):1611-1616.
8. Nusse R, Varmus HE. Many tumors induced by the mouse mammary tumor
virus contain a provirus integrated in the same region of the host
genome. Cell. 1982;31(1):99-109.
9. Hasan MK, Widhopf GF, 2nd, Zhang S, Lam SM, Shen Z, Briggs SP, Parker
BA, and Kipps TJ. Wnt5a induces ROR1 to recruit cortactin to promote
breast-cancer migration and metastasis. NPJ breast cancer. 2019;5:35.
10. Logan CY, Nusse R. The Wnt signaling pathway in development and
disease. Annual review of cell and developmental biology. 2004;
20:781-810.
11. Angers S, Moon RT. Proximal events in Wnt signal transduction.
Nature reviews Molecular cell biology. 2009;10(7):468-477.
12. Li C, Chen H, Hu L, Xing Y, Sasaki T, Villosis MF, Li J, Nishita M,
Minami Y, Minoo P. Ror2 modulates the canonical Wnt signaling in lung
epithelial cells through cooperation with Fzd2. BMC molecular biology.
2008; 9:11.
13. Li M, Zheng J, Luo D, Xu K, Sheng R, MacDonald BT, He X, Zhang X.
Frizzled receptors facilitate Tiki inhibition of Wnt signaling at the
cell surface. EMBO Rep. 2023 Jun 5;24(6):e55873.
14. Bowin CF, Kozielewicz P, Grätz L, Kowalski-Jahn M, Schihada H,
Schulte G. WNT stimulation induces dynamic conformational changes in the
Frizzled-Dishevelled interaction. Sci Signal. 2023 Apr
4;16(779):eabo4974.
15. Kikuchi A, Yamamoto H, Kishida S. Multiplicity of the interactions
of Wnt proteins and their receptors. Cellular signalling.
2007;19(4):659-671.
16. Gordon MD, Nusse R. Wnt signaling: multiple pathways, multiple
receptors, and multiple transcription factors. The Journal of biological
chemistry. 2006;281(32):22429-22433.
17. Clevers H. Wnt/beta-catenin signaling in development and disease.
Cell. 2006;127(3):469-480.
18. Niehrs C, Acebron SP. Mitotic and mitogenic Wnt signalling. The EMBO
journal. 2012;31(12):2705-2713.
19. Fortress AM, Frick KM. Hippocampal Wnt Signaling: Memory Regulation
and Hormone Interactions. The Neuroscientist: a review journal bringing
neurobiology, neurology and psychiatry. 2016;22(3):278-294.
20. van Amerongen R, Mikels A, Nusse R. Alternative wnt signaling is
initiated by distinct receptors. Science signaling. 2008;1(35):re9.
21. Qian D, Jones C, Rzadzinska A, Mark S, Zhang X, Steel KP, Dai X,
Chen P. Wnt5a functions in planar cell polarity regulation in mice.
Developmental biology. 2007;306(1):121-133.
22. Kohn AD, Moon RT. Wnt and calcium signaling:
beta-catenin-independent pathways. Cell calcium. 2005;38(3-4):439-446.
23. Zhang J, Li Y, Wu Y. Research progress on Wnt5a signaling pathway
and its mediated cell movementJ. Life sciences, 2013, (25) 3:289-294.
24. Kilian B, Mansukoski H, Barbosa FC, Ulrich F, Tada M, Heisenberg CP.
The role of Ppt/Wnt5 in regulating cell shape and movement during
zebrafish gastrulation. Mechanisms of development. 2003;120(4):467-476.
25. Kuhl M, Sheldahl LC, Park M, Miller JR, Moon RT. The Wnt/Ca2+
pathway: a new vertebrate Wnt signaling pathway takes shape. Trends in
genetics : TIG. 2000;16(7):279-283.
26. Seifert JR, Mlodzik M. Frizzled/PCP signalling: a conserved
mechanism regulating cell polarity and directed motility. Nature reviews
Genetics. 2007;8(2):126-138.
27. Kuhl M, Geis K, Sheldahl LC, Pukrop T, Moon RT, Wedlich D.
Antagonistic regulation of convergent extension movements in Xenopus by
Wnt/beta-catenin and Wnt/Ca2+ signaling. Mechanisms of development.
2001;106(1-2):61-76.
28. Blumenthal A, Ehlers S, Lauber J, Buer J, Lange C, Goldmann T, Heine
H, Brandt E, Reiling N. The Wingless homolog WNT5A and its receptor
Frizzled-5 regulate inflammatory responses of human mononuclear cells
induced by microbial stimulation. Blood. 2006;108(3):965-973.
29. Gavin BJ, McMahon JA, McMahon AP. Expression of multiple novel
Wnt-1/int-1-related genes during fetal and adult mouse development.
Genes & development. 1990;4(12b):2319-2332.
30. Nusse R, Varmus HE. Wnt genes. Cell. 1992;69(7):1073-1087.
31. Katoh M, Katoh M. Transcriptional mechanisms of WNT5A based on
NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades.
International journal of molecular medicine. 2009;23(6):763-769.
32. Kikuchi A, Yamamoto H, Sato A, Matsumoto S. Wnt5a: its signalling,
functions and implication in diseases. Acta physiologica (Oxford,
England). 2012;204(1):17-33.
33. Cadigan KM, Nusse R. Wnt signaling: a common theme in animal
development. Genes & development. 1997;11(24):3286-3305.
34. Smolich BD, McMahon JA, McMahon AP, Papkoff J. Wnt family proteins
are secreted and associated with the cell surface. Molecular biology of
the cell. 1993;4(12):1267-1275.
35. Mikels AJ, Nusse R. Purified Wnt5a protein activates or inhibits
beta-catenin-TCF signaling depending on receptor context. PLoS biology.
2006;4(4):e115.
36. Green JL, Kuntz SG, Sternberg PW. Ror receptor tyrosine kinases:
orphans no more. Trends in cell biology. 2008;18(11):536-544.
37. Nishita M, Itsukushima S, Nomachi A, Endo M, Wang Z, Inaba D, Qiao
S, Takada S, Kikuchi A, Minami Y. Ror2/Frizzled complex mediates
Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization.
Molecular and cellular biology. 2010;30(14):3610-3619.
38. Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida
I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S,
Minami Y. The receptor tyrosine kinase Ror2 is involved in non-canonical
Wnt5a/JNK signalling pathway. Genes to cells : devoted to molecular &
cellular mechanisms. 2003;8(7):645-654.
39. Mikels A, Minami Y, Nusse R. Ror2 receptor requires tyrosine kinase
activity to mediate Wnt5A signaling. The Journal of biological
chemistry. 2009;284(44):30167-30176.
40. Zhang K, Yao E, Lin C, Chou YT, Wong J, Li J, Wolters PJ, Chuang PT.
A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers
cellular properties required for alveologenesis. eLife. 2020;9.
41. Li C, Smith SM, Peinado N, Gao F, Li W, Lee MK, Zhou B, Bellusci S,
Pryhuber GS, Ho HH, Borok Z, Minoo P. WNT5a-ROR Signaling Is Essential
for Alveologenesis. Cells. 2020;9(2).
42. Puzik K, Tonnier V, Opper I, Eckert A, Zhou L, Kratzer MC, Noble FL,
Nienhaus GU, Gradl D. Lef1 regulates caveolin expression and caveolin
dependent endocytosis, a process necessary for Wnt5a/Ror2 signaling
during Xenopus gastrulation. Scientific reports. 2019;9(1):15645.
43. Weeraratna AT, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner
M, Trent JM. Wnt5a signaling directly affects cell motility and invasion
of metastatic melanoma. Cancer cell. 2002;1(3):279-288.
44. Blanc E, Roux GL, Benard J, Raguenez G. Low expression of Wnt-5a
gene is associated with high-risk neuroblastoma. Oncogene.
2005;24(7):1277-1283.
45. Leris AC, Roberts TR, Jiang WG, Newbold RF, Mokbel K. WNT5A
expression in human breast cancer. Anticancer research.
2005;25(2a):731-734.
46. Okamoto M, Udagawa N, Uehara S, Maeda K, Yamashita T, Nakamichi Y,
Kato H, Saito N, Minami Y, Takahashi N, Kobayashi Y. Noncanonical Wnt5a
enhances Wnt/beta-catenin signaling during osteoblastogenesis.
Scientific reports. 2014;4:4493.
47. Liu Z, Wu HT, Ni YG, Yin YT, Li SX, Liao DF, Qin L. Crosstalk
between Wnt5a and inflammatory signaling in inflammation. Sheng li xue
bao : Acta physiologica Sinica. 2015;67(4):437-445.
48. Pereira C, Schaer DJ, Bachli EB, Kurrer MO, Schoedon G. Wnt5A/CaMKII
signaling contributes to the inflammatory response of macrophages and is
a target for the antiinflammatory action of activated protein C and
interleukin-10. Arteriosclerosis, thrombosis, and vascular biology.
2008;28(3):504-510.
49. Kim J, Chang W, Jung Y, Song K, Lee I. Wnt5a activates THP-1
monocytic cells via a beta-catenin-independent pathway involving JNK and
NF-kappaB activation. Cytokine. 2012;60(1):242-248.
50. Zhao Y, Wang CL, Li RM, Hui TQ, Su YY, Yuan Q, Zhou XD, Ye L. Wnt5a
promotes inflammatory responses via nuclear factor kappaB (NF-kappaB)
and mitogen-activated protein kinase (MAPK) pathways in human dental
pulp cells. The Journal of biological chemistry.
2014;289(30):21028-21039.
51. Rauner M, Stein N, Winzer M, Goettsch C, Zwerina J, Schett G,
Distler JH, Albers J, Schulze J, Schinke T, Bornhäuser M, Platzbecker U,
Hofbauer LC. WNT5A is induced by inflammatory mediators in bone marrow
stromal cells and regulates cytokine and chemokine production. Journal
of bone and mineral research : the official journal of the American
Society for Bone and Mineral Research. 2012;27(3):575-585.
52. Zhao C, Bu X, Wang W, Ma T, Ma H. GEC-derived SFRP5 inhibits
Wnt5a-induced macrophage chemotaxis and activation. PLoS One.
2014;9(1):e85058.
53. Blumenthal A, Ehlers S, Lauber J, Buer J, Lange C, Goldmann T, Heine
H, Brandt E, Reiling N. The Wingless homolog WNT5A and its receptor
Frizzled-5 regulate inflammatory responses of human mononuclear cells
induced by microbial stimulation. Blood. 2006;108(3):965-973.
54. Valencia J, Martinez VG, Hidalgo L, Hernández-López C, Canseco NM,
Vicente A, Varas A, Sacedón R. Wnt5a signaling increases IL-12 secretion
by human dendritic cells and enhances IFN-gamma production by CD4+ T
cells. Immunology letters. 2014;162(1 Pt A):188-199.
55. Catalán V, Gómez-Ambrosi J, Rodríguez A, Pérez-Hernández AI,
Gurbindo J, Ramírez B, Méndez-Giménez L, Rotellar F, Valentí V, Moncada
R, Martí P, Sola I, Silva C, Salvador J, Frühbeck G. Activation of
noncanonical Wnt signaling through WNT5A in visceral adipose tissue of
obese subjects is related to inflammation. The Journal of clinical
endocrinology and metabolism. 2014;99(8):E1407-1417.
56. Fuster JJ, Zuriaga MA, Ngo DT, Farb MG, Aprahamian T, Yamaguchi TP,
Gokce N, Walsh K. Noncanonical Wnt signaling promotes obesity-induced
adipose tissue inflammation and metabolic dysfunction independent of
adipose tissue expansion. Diabetes. 2015;64(4):1235-1248.
57. Linnskog R, Jonsson G, Axelsson L, Prasad CP, Andersson T.
Interleukin-6 drives melanoma cell motility through
p38alpha-MAPK-dependent up-regulation of WNT5A expression. Molecular
oncology. 2014;8(8):1365-1378.
58. Briolay A, Lencel P, Bessueille L, Caverzasio J, Buchet R, Magne D.
Autocrine stimulation of osteoblast activity by Wnt5a in response to
TNF-alpha in human mesenchymal stem cells. Biochemical and biophysical
research communications. 2013;430(3):1072-1077.
59. Bergenfelz C, Medrek C, Ekström E, Jirström K, Janols H, Wullt M,
Bredberg A, Leandersson K. Wnt5a induces a tolerogenic phenotype of
macrophages in sepsis and breast cancer patients. Journal of immunology
(Baltimore, Md : 1950). 2012;188(11):5448-5458.
60. Cohen J. The immunopathogenesis of sepsis. Nature.
2002;420(6917):885-891.
61. Schulte DM, Kragelund D, Müller N, Hagen I, Elke G, Titz A, Schädler
D, Schumacher J, Weiler N, Bewig B, Schreiber S, Laudes M. The
wingless-related integration site-5a/secreted frizzled-related protein-5
system is dysregulated in human sepsis. Clinical and experimental
immunology. 2015;180(1):90-97.
62. Qi J, Hu K, Zhang Y. Changes of serum Wnt5a in patients with burn
sepsis and its significance J. Guizhou journal of medicine, 2015, (39)
1:55-57.
63. Shin J, Yoon Y, Oh DJ. Evaluation of the Wnt signaling pathway as a
prognostic marker in patients with urosepsis. 2020;473(1-2):15-23.
64. Ye J, Feng H. miR-23a-3p inhibits sepsis-induced kidney epithelial
cell injury by suppressing Wnt/β-catenin signaling by targeting wnt5a.
2022;55:e11571.
65. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald
JM, Gibson P, Ohta K, O’Byrne P, Pedersen SE, Pizzichini E, Sullivan SD,
Wenzel SE, Zar HJ. Global strategy for asthma management and prevention:
GINA executive summary. The European respiratory journal. 2008; 31:
143-178.
66. Dietz K, de Los Reyes Jiménez M, Gollwitzer ES, Chaker AM, Zissler
UM, Rådmark OP, Baarsma HA, Königshoff M, Schmidt-Weber CB, Marsland BJ,
Esser-von Bieren J. Age dictates a steroid-resistant cascade of Wnt5a,
transglutaminase 2, and leukotrienes in inflamed airways. The Journal of
allergy and clinical immunology. 2017;139(4):1343-54.e6.
67. Koopmans T, Hesse L, Nawijn MC. Smooth-muscle-derived WNT5A augments
allergen-induced airway remodelling and Th2 type inflammation.
2020;10(1):6754.
68. Januskevicius A, Vaitkiene S, Gosens R, Janulaityte I, Hoppenot D,
Sakalauskas R, Malakauskas K. Eosinophils enhance WNT-5a and TGF-beta1
genes expression in airway smooth muscle cells and promote their
proliferation by increased extracellular matrix proteins production in
asthma. BMC pulmonary medicine. 2016;16(1):94.
69. Han T, Cao Y, Tian L, Feng X, Wang Y. Enhanced expressions of
Wnt5a/JNK signaling pathway-related molecules in the lung tissues of
asthmatic rats. Chinese journal of cellular and molecular immunology.
2015;31(3):325-7, 32.
70. Syed F, Huang CC, Li K, Liu V, Shang T, Amegadzie BY, Griswold DE,
Song XY, Li L. Identification of interleukin-13 related biomarkers using
peripheral blood mononuclear cells. Biomarkers : biochemical indicators
of exposure, response, and susceptibility to chemicals.
2007;12(4):414-423.
71. Liu N, Niu C, Hu XY. Abnormal high expression of Wnt5a in lung
tissues of asthmatic mice J. Journal of immunology, 2015, (31) 3:19-24.
72. Ai X, Shen H, Wang Y, Zhuang J, Zhou Y, Niu F, Zhou Q. Developing a
Diagnostic Model to Predict the Risk of Asthma Based on Ten
Macrophage-Related Gene Signatures. BioMed research international.
2022;2022:3439010.
73. Mirza S, Clay RD, Koslow MA, Scanlon PD. COPD Guidelines: A Review
of the 2018 GOLD Report. Mayo Clinic proceedings. 2018;93(10):1488-1502.
74. Baarsma HA, Skronska-Wasek W, Mutze K, Ciolek F, Wagner DE,
John-Schuster G, Heinzelmann K, Günther A, Bracke KR, Dagouassat M,
Boczkowski J, Brusselle GG, Smits R, Eickelberg O, Yildirim AÖ,
Königshoff M. Noncanonical WNT-5A signaling impairs endogenous lung
repair in COPD. The Journal of experimental medicine.
2017;214(1):143-163.
75. Feller D, Kun J, Ruzsics I, Rapp J, Sarosi V, Kvell K, Helyes Z,
Pongracz JE. Cigarette Smoke-Induced Pulmonary Inflammation Becomes
Systemic by Circulating Extracellular Vesicles Containing Wnt5a and
Inflammatory Cytokines. Frontiers in immunology. 2018;9:1724.
76. Zhu Z, Yin S, Wu K, Lee A, Liu Y, Li H, Song S. Downregulation of
Sfrp5 in insulin resistant rats promotes macrophage-mediated pulmonary
inflammation through activation of Wnt5a/JNK1 signaling. Biochemical and
biophysical research communications. 2018;505(2):498-504.
77. Zhang X, Wang Y, He X, Sun Z, Shi X. Diagnosis of Chronic
Obstructive Pulmonary Disease and Regulatory Mechanism of miR-149-3p on
Alveolar Inflammatory Factors and Expression of Surfactant Proteins A
(SP-A) and D (SP-D) on Lung Surface Mediated by Wnt Pathway. 2022; 2022:
7205016.
78. Ankrah AO, Glaudemans AWJM, Maes A, Van de Wiele C, Dierckx RAJO,
Vorster M, Sathekge MM. Tuberculosis. Seminars in nuclear medicine.
2018;48(2):108-130.
79. Cui J, Li M, Liu W, Zhang B, Sun B, Niu W, Wang Y. Liver kinase B1
overexpression controls mycobacterial infection in macrophages via
FOXO1/Wnt5a signaling. Journal of cellular biochemistry.
2019;120(1):224-231.
80. van der Sar AM, Spaink HP, Zakrzewska A, Bitter W, Meijer AH.
Specificity of the zebrafish host transcriptome response to acute and
chronic mycobacterial infection and the role of innate and adaptive
immune components. Molecular immunology. 2009;46(11-12):2317-2332.
81. Chen D, Li G, Fu X, Li P, Zhang J, Luo L. Wnt5a Deficiency Regulates
Inflammatory Cytokine Secretion, Polarization, and Apoptosis in
Mycobacterium tuberculosis-Infected Macrophages. DNA and cell biology.
2017;36(1):58-66.
82. Strand V, Singh JA. Improved health-related quality of life with
effective disease-modifying antirheumatic drugs: evidence from
randomized controlled trials. The American journal of managed care.
2008;14(4):234-254.
83. McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid
arthritis. Nature reviews Immunology. 2007;7(6):429-442.
84. Karouzakis E, Neidhart M, Gay RE, Gay S. Molecular and cellular
basis of rheumatoid joint destruction. Immunology letters.
2006;106(1):8-13.
85. Sen M, Lauterbach K, El-Gabalawy H, Firestein GS, Corr M, Carson DA.
Expression and function of wingless and frizzled homologs in rheumatoid
arthritis. Proceedings of the National Academy of Sciences of the United
States of America. 2000;97(6):2791-2796.
86. Sen M, Chamorro M, Reifert J, Corr M, Carson DA. Blockade of
Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation.
Arthritis and rheumatism. 2001;44(4):772-781.
87. Rodriguez-Trillo A, Mosquera N, Pena C, Rivas-Tobío F, Mera-Varela
A, Gonzalez A, Conde C. Non-Canonical WNT5A Signaling Through RYK
Contributes to Aggressive Phenotype of the Rheumatoid Fibroblast-Like
Synoviocytes. Frontiers in immunology. 2020;11:555245.
88. Mahmoud DE, Kaabachi W, Sassi N, Mokhtar A, Moalla M, Ammar LB,
Jemmali S, Rekik S, Tarhouni L, Kallel-Sellami M, Cheour E, Laadhar L.
SFRP5 Enhances Wnt5a Induced-Inflammation in Rheumatoid Arthritis
Fibroblast-Like Synoviocytes. Frontiers in immunology. 2021;12:663683.
89. Ross R. Atherosclerosis–an inflammatory disease. The New England
journal of medicine. 1999;340(2):115-126.
90. Malgor R, Bhatt PM, Connolly BA, Jacoby DL, Feldmann KJ, Silver MJ,
Nakazawa M, McCall KD, Goetz DJ. Wnt5a, TLR2 and TLR4 are elevated in
advanced human atherosclerotic lesions. Inflammation research : official
journal of the European Histamine Research Society. 2014;63(4):277-285.
91. Christman MA 2nd, Goetz DJ, Dickerson E, McCall KD, Lewis CJ,
Benencia F, Silver MJ, Kohn LD, Malgor R. Wnt5a is expressed in murine
and human atherosclerotic lesions. American journal of physiology Heart
and circulatory physiology. 2008;294(6):H2864-2870.
92. Bhatt PM, Lewis CJ, House DL, Keller CM, Kohn LD, Silver MJ, McCall
KD, Goetz DJ, Malgor R. Increased Wnt5a mRNA Expression in Advanced
Atherosclerotic Lesions, and Oxidized LDL Treated Human Monocyte-Derived
Macrophages. The open circulation & vascular journal. 2012; 5:1-7.
93. Akoumianakis I, Sanna F. Adipose tissue-derived WNT5A regulates
vascular redox signaling in obesity via USP17/RAC1-mediated activation
of NADPH oxidases. 2019;11(510).
94. Masckauchán TN, Agalliu D, Vorontchikhina M, Ahn A, Parmalee NL, Li
CM, Khoo A, Tycko B, Brown AM, Kitajewski J. Wnt5a signaling induces
proliferation and survival of endothelial cells in vitro and expression
of MMP-1 and Tie-2. Molecular biology of the cell.
2006;17(12):5163-5172.
95. Cheng CW, Yeh JC, Fan TP, Smith SK, Charnock-Jones DS.
Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial
cell proliferation and migration. Biochemical and biophysical research
communications. 2008;365(2):285-290.
96. Woldt E, Terrand J, Mlih M, Matz RL, Bruban V, Coudane F, Foppolo S,
El Asmar Z, Chollet ME, Ninio E, Bednarczyk A, Thiersé D, Schaeffer C,
Van Dorsselaer A, Boudier C, Wahli W, Chambon P, Metzger D, Herz J,
Boucher P. The nuclear hormone receptor PPARgamma counteracts vascular
calcification by inhibiting Wnt5a signalling in vascular smooth muscle
cells. Nature communications. 2012;3:1077.
97. Xin H, Xin F, Zhou S, Guan S. The Wnt5a/Ror2 pathway is associated
with determination of the differentiation fate of bone marrow
mesenchymal stem cells in vascular calcification. International journal
of molecular medicine. 2013;31(3):583-588.
98. Qin L, Hu R, Zhu N, Yao HL, Lei XY, Li SX, Liao DF, Zheng XL. The
novel role and underlying mechanism of Wnt5a in regulating cellular
cholesterol accumulation. Clinical and experimental pharmacology &
physiology. 2014;41(9):671-678.
99. Yang L, Chu Y, Wang Y, Zhao X, Xu W, Zhang P, Liu X, Dong S, He W,
Gao C. siRNA-mediated silencing of Wnt5a regulates inflammatory
responses in atherosclerosis through the MAPK/NF-kappaB pathways.
International journal of molecular medicine. 2014;34(4):1147-1152.
100. Zhang F, Sun P, Yuan N. miR-141-3p Reduces Cell Migration and
Proliferation in an In Vitro Modelof Atherosclerosis by Targeting Wnt5a.
Journal of investigative surgery: the official journal of the Academy of
Surgical Research. 2022;35(3):598-604.
101. Awan S, Lambert M. Wnt5a Promotes Lysosomal Cholesterol Egress and
Protects Against Atherosclerosis. 2022;130(2):184-199.
102. Habas R, Dawid IB, He X. Coactivation of Rac and Rho by
Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes &
development. 2003;17(2):295-309.
103. Shi Y, Li H, Gu J, Gong Y, Xie X, Liao D, Qin L. Wnt5a/Ror2
promotes vascular smooth muscle cells proliferation via activating PKC.
Folia histochemica et cytobiologica. 2022;60(3):271-279.
104. Shi J, Zhou B, Tian Z. DOCK9 antisense RNA2 interacts with LIN28B
to stabilize Wnt5a and boosts proliferation and migration of oxidized
low densitylipoprotein-induced vascular smooth muscle cells.
Bioengineered. 2022;13(3):7564-7578.
105. Lowes MA, Bowcock AM, Krueger JG. Pathogenesis and therapy of
psoriasis. Nature. 2007;445(7130):866-873.
106. Reischl J, Schwenke S, Beekman JM, Mrowietz U, Sturzebecher S,
Heubach JF. Increased expression of Wnt5a in psoriatic plaques. The
Journal of investigative dermatology. 2007;127(1):163-169.
107. Tian F, Mauro TM, Li Z. The pathological role of Wnt5a in psoriasis
and psoriatic arthritis. Journal of cellular and molecular medicine.
2019;23(9):5876-5883.
108. Romanowska M, Evans A, Kellock D, Bray SE, McLean K, Donandt S,
Foerster J. Wnt5a exhibits layer-specific expression in adult skin, is
upregulated in psoriasis, and synergizes with type 1 interferon. PLoS
One. 2009;4(4):e5354.
109. Siemes C, Quast T, Klein E, Bieber T, Hooper NM, Herzog V.
Normalized proliferation of normal and psoriatic keratinocytes by
suppression of sAPPalpha-release. The Journal of investigative
dermatology. 2004;123(3):556-563.
110. Suarez-Farinas M, Fuentes-Duculan J, Lowes MA, Krueger JG. Resolved
psoriasis lesions retain expression of a subset of disease-related
genes. The Journal of investigative dermatology. 2011;131(2):391-400.
111. Ning X, Zhang D, Wang Y, Huo J, Huang Y, Guo Y, Li Z, Zhang Y. The
Levels of Wnt5a and Its Receptors Frizzled5 and Frizzled2 as
Immunohistochemical Biomarkers of Severity of Psoriasis.
2021;14:1651-1656.