Abstract
Wnt5a plays an important role in the process of cell development and maturation and is closely related to various diseases, such as malignant tumors, metabolic disorders, fibrosis, growth and development. Recent studies have shown that Wnt5a expression regulation and signal transduction are closely related to inflammatory response. This paper comprehensively reviews the latest research progress on the relationship between Wnt5a and various inflammatory diseases, such as sepsis, asthma, chronic obstructive pulmonary disease, tuberculosis, rheumatoid arthritis, atherosclerosis, psoriasis vulgare, etc. The mechanism of Wnt5a protein in the pathogenesis of these diseases was elucidated, which provided a basis for the prevention and treatment of inflammatory diseases with Wnt5a as a possible target in the future.
Wnt is a family of secretory glycoproteins that regulates a series of cellular behaviors through receptor-mediated signaling pathways on the cell surface (1). Recent studies have demonstrated that Wnt signaling pathway plays an important role in regulating cell proliferation, embryonic development, differentiation, polarity, migration, and inflammation (2-6). Wnt5a, a member of the highly conserved Wnt protein family, has been reported in the development and maturation of tissues and organs and is closely related to various diseases, such as malignant tumors, metabolic disorders, fibrosis. In particular, recent studies have shown that Wnt5a signaling is also involved in the inflammatory diseases (7). In this paper, the Wnt family and the signaling pathway, the relationship between Wnt5a and inflammatory factors, and the relationship between Wnt5a and inflammatory signal transduction pathway is expounded. Meanwhile, the latest results of Wnt5a protein in sepsis, bronchial asthma, Chronic obstructive pulmonary disease (COPD), tuberculosis, rheumatoid arthritis, atherosclerosis, psoriasis Vulgaris and other inflammatory diseases in recent years are reviewed. It means to clarify the mechanism of action of Wnt5a rotein in the pathogenesis of inflammatory diseases, to provide the basis for the prevention and
treatment of inflammatory diseases with Wnt5a as a target in the future.