Abstract
Wnt5a plays an important role in the process of cell development and
maturation and is closely related to various diseases, such as malignant
tumors, metabolic disorders, fibrosis, growth and development. Recent
studies have shown that Wnt5a expression regulation and signal
transduction are closely related to inflammatory response. This paper
comprehensively reviews the latest research progress on the relationship
between Wnt5a and various inflammatory diseases, such as sepsis, asthma,
chronic obstructive pulmonary disease, tuberculosis, rheumatoid
arthritis, atherosclerosis, psoriasis vulgare, etc. The mechanism of
Wnt5a protein in the pathogenesis of these diseases was elucidated,
which provided a basis for the prevention and treatment of inflammatory
diseases with Wnt5a as a possible target in the future.
Wnt is a family of secretory glycoproteins that regulates a series of
cellular behaviors through receptor-mediated signaling pathways on the
cell surface (1). Recent studies have demonstrated that Wnt signaling
pathway plays an important role in regulating cell proliferation,
embryonic development, differentiation, polarity, migration, and
inflammation (2-6). Wnt5a, a member of the highly conserved Wnt protein
family, has been reported in the development and maturation of tissues
and organs and is closely related to various diseases, such as malignant
tumors, metabolic disorders, fibrosis. In particular, recent studies
have shown that Wnt5a signaling is also involved in the inflammatory
diseases (7). In this paper, the Wnt family and the signaling pathway,
the relationship between Wnt5a and inflammatory factors, and the
relationship between Wnt5a and inflammatory signal transduction pathway
is expounded. Meanwhile, the latest results of Wnt5a protein in sepsis,
bronchial asthma, Chronic obstructive pulmonary disease (COPD),
tuberculosis, rheumatoid arthritis, atherosclerosis, psoriasis Vulgaris
and other inflammatory diseases in recent years are reviewed. It means
to clarify the mechanism of action of Wnt5a rotein in the pathogenesis
of inflammatory diseases, to provide the basis for the prevention and
treatment of inflammatory diseases with Wnt5a as a target in the future.