5. Prospect
This paper reviews Wnt5a and it signaling pathways, its relationship
with inflammatory factors, and its role in the pathogenesis of
inflammatory diseases. Wnt5a has a variety of signal transduction modes
and signaling pathways in cells, and there are different
cross-regulations in each signal transduction mode and signaling
pathway. Wnt5a mainly induces cells to secrete inflammatory factors in
proinflammatory process. But in a few cases, it also participates in
process of inhibiting inflammation. Meanwhile, inflammatory factors can
also react on Wnt5a to regulate its expression level, which maintains a
whole regulatory balance. Therefore, Wnt5a plays a bothway role in the
transduction of inflammatory signaling pathways and inflammatory
diseases. Its specific function varies according to the type of the
receptors or cells it binds to. Excessive activation and inhibition of
the Wnt5a signaling pathway may lead to the occurrence of various
inflammatory diseases. In this paper, the Wnt family and it signaling
pathways, Wnt5a and its relationship with inflammatory factors were
systematically demonstrated; the role of Wnt5a in inflammatory diseases
such as sepsis, bronchial asthma, COPD, tuberculosis, rheumatoid
arthritis, atherosclerosis, psoriasis Vulgare were also reviewed.
According to the current research results, Wnt5a pathway is a potential
candidate target for therapeutic intervention in inflammatory diseases.
For example, COX-2 prevents the production of inflammatory
prostaglandins to achieve anti-inflammatory, analgesic and antipyretic
effects; inhibiting Wnt5a/JNKl pathway to reduce inflammation in
patients with chronic obstructive pulmonary disease through Sfrp5;
blocking of Wnt5a/ FZD5 signaling pathway to treat rheumatoid arthritis;
Upregulation of miR-23a-3p may alleviate LPS-induced cell injury by
targeting wnt5a and inactivating Wnt/β-catenin pathway, which may serve
as a novel therapeutic target for sepsis-associated acute kidney injury;
Genetic analysis of patients with psoriasis Vulgaris has a very positive
effect on the prevention and treatment of relapse and strengthening
clinical management. Thus, further studies on the specific receptors
Wnt5a bounded and specific signaling pathways involved are needed to
find new targets for the treatment of related diseases, which may be
helpful to the clinical treatment and prevention.