5. Prospect
This paper reviews Wnt5a and it signaling pathways, its relationship with inflammatory factors, and its role in the pathogenesis of inflammatory diseases. Wnt5a has a variety of signal transduction modes and signaling pathways in cells, and there are different cross-regulations in each signal transduction mode and signaling pathway. Wnt5a mainly induces cells to secrete inflammatory factors in proinflammatory process. But in a few cases, it also participates in process of inhibiting inflammation. Meanwhile, inflammatory factors can also react on Wnt5a to regulate its expression level, which maintains a whole regulatory balance. Therefore, Wnt5a plays a bothway role in the transduction of inflammatory signaling pathways and inflammatory diseases. Its specific function varies according to the type of the receptors or cells it binds to. Excessive activation and inhibition of the Wnt5a signaling pathway may lead to the occurrence of various inflammatory diseases. In this paper, the Wnt family and it signaling pathways, Wnt5a and its relationship with inflammatory factors were systematically demonstrated; the role of Wnt5a in inflammatory diseases such as sepsis, bronchial asthma, COPD, tuberculosis, rheumatoid arthritis, atherosclerosis, psoriasis Vulgare were also reviewed. According to the current research results, Wnt5a pathway is a potential candidate target for therapeutic intervention in inflammatory diseases. For example, COX-2 prevents the production of inflammatory prostaglandins to achieve anti-inflammatory, analgesic and antipyretic effects; inhibiting Wnt5a/JNKl pathway to reduce inflammation in patients with chronic obstructive pulmonary disease through Sfrp5; blocking of Wnt5a/ FZD5 signaling pathway to treat rheumatoid arthritis; Upregulation of miR-23a-3p may alleviate LPS-induced cell injury by targeting wnt5a and inactivating Wnt/β-catenin pathway, which may serve as a novel therapeutic target for sepsis-associated acute kidney injury; Genetic analysis of patients with psoriasis Vulgaris has a very positive effect on the prevention and treatment of relapse and strengthening clinical management. Thus, further studies on the specific receptors Wnt5a bounded and specific signaling pathways involved are needed to find new targets for the treatment of related diseases, which may be helpful to the clinical treatment and prevention.