Conclusion
Different studies showed that NCI in patients with a PBT can be
mitigated by diverse and multimodal interventions. Nevertheless, results
are very heterogeneous both across and among different types of
interventions. Therefore, harmonization of study designs and endpoints
is essential to enable comparison of different interventions.
Furthermore, efforts should be made to provide patient-tailored
interventions, addressing individual neurocognitive performance and
psychosocial needs of patients with a PBT. Finally, multimodal
interventions, simultaneously targeting the diverse aspects involved in
cognitive functioning (i.e. physical health, brain plasticity) from
different angles, might be valuable to assess in future trials.
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