Conclusion
Different studies showed that NCI in patients with a PBT can be mitigated by diverse and multimodal interventions. Nevertheless, results are very heterogeneous both across and among different types of interventions. Therefore, harmonization of study designs and endpoints is essential to enable comparison of different interventions. Furthermore, efforts should be made to provide patient-tailored interventions, addressing individual neurocognitive performance and psychosocial needs of patients with a PBT. Finally, multimodal interventions, simultaneously targeting the diverse aspects involved in cognitive functioning (i.e. physical health, brain plasticity) from different angles, might be valuable to assess in future trials.
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