References:
Al-Qassab Y, Grassilli S, Brugnoli F, Vezzali F, Capitani S, Bertagnolo V (2018). Protective role of all-trans retinoic acid (ATRA) against hypoxia-induced malignant potential of non-invasive breast tumor derived cells. BMC Cancer 18 : 1194.
Arancibia A, Gai MN, Chávez J, Paulos C, Pinilla E, González C et al. (2005). Pharmacokinetics of prednisolone in man during acute and chronic exposure to high altitude. Int J Clin Pharmacol Ther43: 85-91.
Arancibia A, Paulos C, Chávez J, Ritschel W A (2003). Pharmacokinetics of lithium in healthy volunteers after exposure to high altitude.Int J Clin Pharmacol Ther 41: 200-206.
Bai X, Liu G, Yang J, Zhu J, Li X (2022). Gut microbiota as the potential mechanism to mediate drug metabolism under high-altitude hypoxia. Curr Drug Metab 23 : 8-20.
Bautista-Olivier CD, Elizondo G (2022). PXR as the tipping point between innate immune response, microbial infections, and drug metabolism.Biochemical Pharmacology 202 :115147.
Bonazzi A, Mastyugin V, Mieyal PA, Dunn MW, Laniado-Schwartzman M (2000). Regulation of cyclooxygenase-2 by hypoxia and peroxisome proliferators in the corneal epithelium. J Biol Chem275 : 2837-2844.
Cabrera-Cano A, Dávila-Borja VM, Juárez-Méndez S, Marcial-Quino J, Gómez-Manzo S, Castillo-Rodríguez RA (2021). Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia. Cell Biochem Funct39 : 478-487.
Cai W, Liu S, Liu Z, Hou S, Lv Q, Cui H et al. (2020). Downregulation of lung miR-203a-3p expression by high-altitude hypoxia enhances VEGF/Notch signaling. Aging (Albany NY) 12 : 4247-4267.
Capozzi ME, McCollum GW, Penn JS (2014). The role of cytochrome P450 epoxygenases in retinal angiogenesis. Invest Ophthalmol Vis Sci55 : 4253-4260.
Chen H, Cheng Z, Wang M, Huang Q, Zheng D, Huang Q et al. (2024). Circ_0020887 silencing combats hypoxic-induced cardiomyocyte injury in an MiR-370-3p/CYP1B1-dependent manner. Int Heart J 65: 308-17.
Chen L, Ackerman R, Saleh M, Gotlinger KH, Kessler M, Mendelowitz LG et al. (2014). 20-HETE regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in vivo.J Pharmacol Exp Ther 348 : 442-451.
Chen L, Bao Y, Piekos SC, Zhu K, Zhang L, Zhong XB (2018). A transcriptional regulatory network containing nuclear receptors and long noncoding RNAs controls basal and drug-induced expression of cytochrome P450s in HepaRG cells. Mol Pharmacol 94 : 749-759.
Chen L, Joseph G, Zhang FF, Nguyen H, Jiang H, Gotlinger Kh et al. (2016). 20-HETE contributes to ischemia-induced angiogenesis.Vascul Pharmacol 83 : 57-65.
Chen X, An Z, Wei L, Zhang J, Li J, Wang Z et al. (2022). Vitamin D(3) metabolic enzymes in plateau zokor (myospalax baileyi) and plateau pika (ochotona curzoniae): expression and response to hypoxia. Animals (Basel) 12 :2371.
Chen X, Liu X, Li B, Zhang Q, Wang J, Zhang W et al. (2017). Cold inducible RNA binding rrotein is involved in chronic hypoxia induced neuron apoptosis by down-regulating HIF-1α expression and regulated by microRNA-23a. Int J Biol Sci 13 : 518-531.
Cheng S, Wu T, Li Y, Huang J, Cai T (2020). Romidepsin (FK228) in a mouse model of lipopolysaccharide-induced acute kidney injury is associated with down-regulation of the CYP2E1 gene. Med Sci Monit26 : e918528.
Chiang TS, Yang KC, Chiou LL, Huang GT, Lee HS (2014). Enhancement of CYP3A4 activity in Hep G2 cells by lentiviral transfection of hepatocyte nuclear factor-1 alpha. PLoS One 9 : e94885.
Cizkova K, Konieczna A, Erdosova B, Lichnovska R, Ehrmann J (2012). Peroxisome proliferator-activated receptors in regulation of cytochromes P450: new way to overcome multidrug resistance? J Biomed Biotechnol 2012 : 656428.
Coelho NR, Tomkiewicz C, Correia MJ, Gonçalves-Dias C, Barouki R, Pereira SA et al. (2020). First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Pharmacol Res 159 : 104869.
Dannenberg LO, Edenberg HJ (2006). Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. BMC Genomics7 : 181.
Dolly A, Pötgens SA, Thibaut MM, Neyrinck AM, de Castro GS, Galbert C et al. (2023). Impairment of aryl hydrocarbon receptor signalling promotes hepatic disorders in cancer cachexia. J Cachexia Sarcopenia Muscle14 : 1569-1582.
du Souich P, Hartemann D, Saunier C (1993). Effect of acute and chronic moderate hypoxia on diltiazem kinetics and metabolism in the dog.Pharmacology 47 : 378-385.
du Souich P, Varin F, Courteau H (1986). Effect of hypercapnia and/or hypoxemia and metabolic acidosis on kinetics and concentrations of phenytoin in the cerebrospinal fluid of conscious rabbits.Neuropharmacology 25 : 857-862.
Duan Y, Bai X, Yang J, Zhou Y, Gu W, Liu G, et al. (2022). Exposure to high-altitude environment is associated with drug transporters change: microRNA-873-5p-mediated alteration of function and expression levels of drug transporters under hypoxia. Drug Metab Dispos 50 : 174-186.
Duan YB, Zhu JB, Yang JX, Liu GQ, Bai X, Qu N et al. (2020). Regulation of high-altitude hypoxia on the transcription of CYP450 and UGT1A1 mediated by PXR and CAR. Front Pharmacol 11 : 574176.
Dunvald ACD, Jarvinen E, Mortensen C, Stage TB (2022). Clinical and molecular perspectives on inflammation-mediated regulation of drug metabolism and transport. Clinical Pharmacology & Therapeutics112 : 277-290.
Earley S, Pastuszyn A, Walker BR (2003). Cytochrome p-450 epoxygenase products contribute to attenuated vasoconstriction after chronic hypoxia. Am J Physiol Heart Circ Physiol 285 : H127-136.
Fradette C, Batonga J, Teng S, Piquette-Miller M, du Souich P (2007). Animal models of acute moderate hypoxia are associated with a down-regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and up-regulation of CYP3A6 and P-glycoprotein in liver. Drug Metab Dispos35 : 765-771.
Fradette C, Bleau AM, Pichette V, Chauret N, Du Souich P (2002). Hypoxia-induced down-regulation of CYP1A1/1A2 and up-regulation of CYP3A6 involves serum mediators. Br J Pharmacol 137 : 881-891.
Fradette C, du Souich P (2003). Hypoxia-inducible factor-1 and activator protein-1 modulate the upregulation of CYP3A6 induced by hypoxia.Br J Pharmacol 140 : 1146-1154.
Gebremedhin D, Yamaura K, Harder DR (2008). Role of 20-HETE in the hypoxia-induced activation of Ca2+-activated K+ channel currents in rat cerebral arterial muscle cells. Am J Physiol Heart Circ Physiol294 : H107-120.
Gola S, Gupta A, Keshri GK, Nath M, Velpandian T (2016). Evaluation of hepatic metabolism and pharmacokinetics of ibuprofen in rats under chronic hypobaric hypoxia for targeted therapy at high altitude. J Pharm Biomed Anal 121 : 114-122.
Gola S, Keshri GK, Gupta A (2013). Hepatic metabolism of ibuprofen in rats under acute hypobaric hypoxia. Exp Toxicol Pathol65 : 751-758.
Gong W, Liu S, Xu P, Fan M, Xue M (2015). Simultaneous quantification of diazepam and dexamethasone in plasma by high-performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic comparison between normoxic and hypoxic rats.Molecules 20 : 6901-6912.
Goswami AR, Dutta G, Ghosh T (2014). Effects of vitamin C on the hypobaric hypoxia-induced immune changes in male rats. Int J Biometeorol 58 : 1961-1971.
Goyal R, Billings TL, Mansour T, Martin C, Baylink DJ, Longo LD et al. (2016). Vitamin D status and metabolism in an ovine pregnancy model: effect of long-term, high-altitude hypoxia. Am J Physiol Endocrinol Metab 310 : E1062-1071.
Hashimoto R, Joshi SR, Jiang H, Capdevila JH, McMurtry IF, Laniado Schwartzman M et al. (2017). Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol 313 : H293-h303.
Huang L, Zhang X, Luo L, Mu H, Li W, Wang R (2022). Effects of high-altitude environment on pharmacokinetic parameters of gliquidone in rats. Zhejiang Da Xue Xue Bao Yi Xue Ban 51 : 389-396.
Huang Q, Luo L, Wang Z, li W, Wang W (2023). Effects of plateau hypoxia on the pharmacokinetics and pharmacodynamics of atorvastatin calcium in hyperlipidemic rats. Chinese Pharmacological Bulletin 39 : 1227-33.
Jacob A, Potin S, Saubaméa B, Crete D, Scherrmann JM, Curis E et al. (2015). Hypoxia interferes with aryl hydrocarbon receptor pathway in hCMEC/D3 human cerebral microvascular endothelial cells. J Neurochem 132 : 373-383.
Jiang W, Wu H, Yu X, Wang Y, Gu W, Wei W et al. (2021). Third-hand smoke exposure is associated with abnormal serum melatonin level via hypomethylation of CYP1A2 promoter: Evidence from human and animal studies. Environ Pollut 277 : 116669.
Jiang Z, Zheng X, Wang W, Qiu L, Yang L, Jiang M et al. (2021). CYP2C9 inhibits the invasion and migration of esophageal squamous cell carcinoma via downregulation of HDAC. Mol Cell Biochem476 : 2011-2020.
Jin T, Lu H, Zhang Z, Wang Y, Yang W, Wang Y et al. (2022). CYP2S1 gene methylation among High-altitude pulmonary edema. Gene834 : 146590.
Jürgens G, Christensen HR, Brøsen K, Sonne J, Loft S, Olsen NV (2002). Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans. Clin Pharmacol Ther 71 : 214-220.
Kamimori GH, Eddington ND, Hoyt RW, Fulco CS, Lugo S, Durkot MJ et al. (1995). Effects of altitude (4300 m) on the pharmacokinetics of caffeine and cardio-green in humans. Eur J Clin Pharmacol 48 : 167-170.
Kandhi S, Alruwaili N, Wolin MS, Sun D, Huang A (2019). Reciprocal actions of constrictor prostanoids and superoxide in chronic hypoxia-induced pulmonary hypertension: roles of EETs. Pulm Circ 9 : 2045894019895947.
Kapil U, Pandey RM, Goswami R, Sharma B, Sharma N, Ramakrishnan L et al. (2017). Prevalence of Vitamin D deficiency and associated risk factors among children residing at high altitude in Shimla district, Himachal Pradesh, India. Indian J Endocrinol Metab 21 : 178-183.
Kassie F, Anderson LB, Higgins L, Pan Y, Matise I, Negia M et al. (2008). Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice. Carcinogenesis29 : 610-619.
Krkoška M, Nekvindová J, Nevědělová K, Zubáňová V, Radová L, Vondráček J et al. (2022). Role of miR-653 and miR-29c in downregulation of CYP1A2 expression in hepatocellular carcinoma. Pharmacol Rep74 : 148-158.
Kronfol MM, Jahr FM, Dozmorov MG, Phansalkar PS, Xie LY, Aberg KA et al. (2020). DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver. Geroscience 42 : 819-832.
Kuban W, Daniel WA (2021). Cytochrome P450 expression and regulation in the brain. Drug Metab Rev 53 : 1-29.
Kudo T, Zhao ML, Jeknić S, Kovary KM, LaGory EL, Covert MW et al. (2023). Context-dependent regulation of lipid accumulation in adipocytes by a HIF1α-PPARγ feedback network. Cell Syst 14 : 1074-1086.
Kugler N, Klein K, Zanger UM (2020). MiR-155 and other microRNAs downregulate drug metabolizing cytochromes P450 in inflammation.Biochem Pharmacol 171 : 113725.
Legendre C, Hori T, Loyer P, Aninat C, Ishida S, Glaise D et al. (2009). Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression. Eur J Cancer 45 : 2882-2892.
Leveelahti L, Leskinen P, Leder EH, Waser W, Nikinmaa M (2011). Responses of threespine stickleback (Gasterosteus aculeatus, L) transcriptome to hypoxia. Comp Biochem Physiol Part D Genomics Proteomics 6 : 370-381.
Li L, Wang X, Wang S, Wen L, Zhang H (2024). Altitude effect on propofol pharmacokinetics in rats. Curr Drug Metab .
Li X, Wang X, Li Y, Yuan M, Zhu J, Su X et al. (2014). Effect of exposure to acute and chronic high-altitude hypoxia on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in rats.Pharmacology 93 : 76-83.
Li X, Wang X, Li Y, Zhu J, Su X, Yao X et al. (2014). The activity, protein, and mRNA expression of CYP2E1 and CYP3A1 in rats after exposure to acute and chronic high altitude hypoxia. High Alt Med Biol15 : 491-496.
Li XY, Gao F, Li ZQ, Guan W, Feng WL, Ge RL (2009). Comparison of the pharmacokinetics of sulfamethoxazole in male Chinese volunteers at low altitude and acute exposure to high altitude versus subjects living chronically at high altitude: an open-label, controlled, prospective study. Clin Ther 31 : 2744-2754.
Lin Z, Lu Y, Yu G, Teng H, Wang B, Yang Y et al. (2023). Genome-wide DNA methylation landscape of four Chinese populations and epigenetic variation linked to Tibetan high-altitude adaptation. Sci China Life Sci 66 : 2354-2369.
Liu M, Alkayed NJ (2005). Hypoxic preconditioning and tolerance via hypoxia inducible factor (HIF) 1alpha-linked induction of P450 2C11 epoxygenase in astrocytes. J Cereb Blood Flow Metab 25 : 939-948.
Lkhagvadorj K, Meyer KF, Verweij LP, Kooistra W, Reinders-Luinge M, Dijkhuizen HW et al. (2020). Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring. Epigenetics15 :1370-1385.
Lu Z, Yuan C, Li J, Guo T, Yue Y, Niu C et al. (2021). Comprehensive analysis of long non-coding RNA and mRNA transcriptomes related to hypoxia adaptation in tibetan sheep. Front Vet Sci 8 : 801278.
Luo B, Li J, Yang T, Li W, Zhang J, Wang C et al. (2018). Evaluation of renal excretion and pharmacokinetics of furosemide in rats after acute exposure to high altitude at 4300 m. Biopharm Drug Dispos39 : 378-387.
Luo B, Wang R, Li W, Yang T, Wang C, Lu H et al. (2017). Pharmacokinetic changes of norfloxacin based on expression of MRP2 after acute exposure to high altitude at 4300m. Biomed Pharmacother 89 : 1078-1085.
Luo B, Zhang J, Zhang T, Zhang J, Li W, Wang C, et al (2017). Effect of amoxicillin on the expression of PEPT1 and pharmacokinetics upon acute hypoxia at high altitude in rat. Acta Pharmaceutica Sinica 52 : 1715-21.
Mastyugin V, Aversa E, Bonazzi A, Vafaes C, Mieyal P, Schwartzman ML (1999). Hypoxia-induced production of 12-hydroxyeicosanoids in the corneal epithelium: involvement of a cytochrome P-4504B1 isoform.J Pharmacol Exp Ther 289 : 1611-1619.
Mastyugin V, Mezentsev A, Zhang WX, Ashkar S, Dunn MW, Laniado-Schwartzman M (2004). Promoter activity and regulation of the corneal CYP4B1 gene by hypoxia. J Cell Biochem 91 : 1218-1238.
Mata-Greenwood E, Westenburg HCA., Zamudio S, Illsley NP, Zhang L (2023). Decreased vitamin D levels and altered placental vitamin D gene expression at high altitude: role of genetic ancestry. Int J Mol Sci 24 : 3389
Matthews O, Morrison EE, Tranter JD, Starkey Lewis P, Toor IS, Srivastava A et al. (2020). Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells. EBioMedicine62 : 103092.
Mazure NM, Nguyen TL, Danan JL (2001). Severe hypoxia specifically downregulates hepatocyte nuclear factor-4 gene expression in HepG2 human hepatoma cells. Tumour Biol 22 : 310-317.
Michaelis UR, Fisslthaler B, Barbosa-Sicard E, Falck JR, Fleming I, Busse R (2005). Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis. J Cell Sci 118 : 5489-5498.
Michaelis UR, Xia N, Barbosa-Sicard E, Falck JR, Fleming I (2008). Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells. Invest Ophthalmol Vis Sci 49 : 1242-1247.
Moon Y, Park B, Park H (2016). Hypoxic repression of CYP7A1 through a HIF-1α- and SHP-independent mechanism. BMB Rep 49 : 173-178.
Morgan ET (2009). Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics.Clin Pharmacol Ther 85 : 434-438.
Morgan ET, Li-Masters T, Cheng PY (2002). Mechanisms of cytochrome P450 regulation by inflammatory mediators. Toxicology181-182 : 207-210.
Myers DA, Hyatt K, Mlynarczyk M, Bird IM, Ducsay CA (2005). Long-term hypoxia represses the expression of key genes regulating cortisol biosynthesis in the near-term ovine fetus. Am J Physiol Regul Integr Comp Physiol 289 : R1707-1714.
Myung SJ, Yoon JH, Yu SJ (2012). STAT3 & Cytochrome P450 2C9: a novel signaling pathway in liver cancer stem cells. Biomed Pharmacother66 : 612-616.
Nishimura T, Motoi M, Toyoshima H, Kishida F, Shin S, Katsumura T et al. (2023). Endocrine, inflammatory and immune responses and individual differences in acute hypobaric hypoxia in lowlanders. Sci Rep13 : 12659.
Oguro A, Sakamoto K, Funae Y, Imaoka S (2011). Overexpression of CYP3A4, but not of CYP2D6, promotes hypoxic response and cell growth of Hep3B cells. Drug Metab Pharmacokinet 26 : 407-415.
Pelham CJ, Drews EM, Agrawal DK (2016). Vitamin D controls resistance artery function through regulation of perivascular adipose tissue hypoxia and inflammation. J Mol Cell Cardiol 98 : 1-10.
Penaloza CG, Cruz M, Germain G, Jabeen S, Javdan M, Lockshin RA et al. (2020). Higher sensitivity of female cells to ethanol: methylation of DNA lowers Cyp2e1, generating more ROS. Cell Commun Signal18 : 111.
Perreault S, Saunier C, Duvivier C, Peslin R, Ong H, Du Souich P (1994). Influence of chronic hypoxia on salbutamol tissular concentrations and on respiratory resistance in anesthetized rabbits. Am J Respir Crit Care Med 150 : 1374-1378.
Piguet AC, Stroka D, Zimmermann A, Dufour JF (2009). Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN.Clin Sci (Lond) 118 : 401-410.
Pokreisz P, Fleming I, Kiss L, Barbosa-Sicard E, Fisslthaler B, Falck JR et al. (2006). Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling.Hypertension 47 : 762-770.
Pu J, Vinitchaikul P, Gu Z, Mao H, Zhang F (2021). The use of metabolomics to reveal differences in functional substances of milk whey of dairy buffaloes raised at different altitudes. Food Funct12 : 5440-5450.
Rahman MS, Thomas P (2012). Effects of hypoxia exposure on hepatic cytochrome P450 1A (CYP1A) expression in Atlantic croaker: molecular mechanisms of CYP1A down-regulation. PLoS One 7 : e40825.
Rahman MS, Thomas P (2021). Molecular characterization and expression of cytochrome P450 aromatase in atlantic croaker brain: regulation by antioxidant status and nitric oxide synthase during hypoxia stress.Front Physiol 12 : 720200.
Ramakrishnan SK, Taylor M, Qu A, Ahn SH, Suresh MV, Raghavendran K et al. (2014). Loss of von Hippel-Lindau protein (VHL) increases systemic cholesterol levels through targeting hypoxia-inducible factor 2α and regulation of bile acid homeostasis. Mol Cell Biol 34 : 1208-1220.
Ritschel WA, Paulos C, Arancibia A, Agrawal MA, Wetzelsberger KM, Lücker PW (1998). Pharmacokinetics of acetazolamide in healthy volunteers after short- and long-term exposure to high altitude. J Clin Pharmacol38 : 533-539.
Ritschel WA, Paulos C, Arancibia A, Pezzani M, Agrawal MA, Wetzelsberger KM et al. (1996). Pharmacokinetics of meperidine in healthy volunteers after short- and long-term exposure to high altitude. J Clin Pharmacol 36 : 610-616.
Rivera SP, Wang F, Saarikoski ST, Taylor RT, Chapman B, Zhang R et al. (2007). A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia. J Biol Chem282 : 10881-10893.
Ruhr I, Bierstedt J, Rhen T, Das D, Singh SK, Miller S et al. (2021). Developmental programming of DNA methylation and gene expression patterns is associated with extreme cardiovascular tolerance to anoxia in the common snapping turtle. Epigenetics Chromatin 14 : 42.
Sato Y, Tsuyama T, Sato C, Karim MF, Yoshizawa T, Inoue M et al. (2017). Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase. J Biol Chem292 : 8716-8728.
Selwyn FP, Cheng SL, Klaassen CD, Cui JY (2016). Regulation of hepatic drug-metabolizing enzymes in germ-free mice by conventionalization and probiotics. Drug Metab Dispos 44 : 262-274.
Shaw S, Kumar U, Bhaumik G, Reddy MPK, Kumar B, Ghosh D (2020). Alterations of estrous cycle, 3β hydroxysteroid dehydrogenase activity and progesterone synthesis in female rats after exposure to hypobaric hypoxia. Sci Rep 10 : 3458.
Shi LX, Wang X, Wu Q, Sun X, Wan Z, Li L et al. (2017). Hepatic Cyp1a2 expression reduction during inflammation elicited in a rat model of intermittent hypoxia. Chin Med J (Engl) 130 : 2585-2590.
Śliwicka E, Cisoń T, Kasprzak Z, Nowak A, Pilaczyńska-Szcześniak Ł (2017). Serum irisin and myostatin levels after 2 weeks of high-altitude climbing. PLoS One 12 : e0181259.
Smutny T, Hyrsova L, Braeuning A, Ingelman-Sundberg M, Pavek P (2021). Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism. Archives of Toxicology 95 : 11-25.
Streit M, Göggelmann C, Dehnert C, Burhenne J, Riedel KD, Menold E et al. (2005). Cytochrome P450 enzyme-mediated drug metabolism at exposure to acute hypoxia (corresponding to an altitude of 4,500 m). Eur J Clin Pharmacol 61 : 39-46.
Strielkov I, Krause NC, Knoepp F, Alebrahimdehkordi N, Pak O, Garcia C et al. (2020). Cytochrome P450 epoxygenase-derived 5,6-epoxyeicosatrienoic acid relaxes pulmonary arteries in normoxia but promotes sustained pulmonary vasoconstriction in hypoxia. Acta Physiol (Oxf) 230 : e13521.
Sukmawan R, Hoetama E, Suridanda Danny S, Giantini A, Listiyaningsih E, Gilang Rejeki V et al. (2021). Increase in the risk of clopidogrel resistance and consequent TIMI flow impairment by DNA hypomethylation of CYP2C19 gene in STEMI patients undergoing primary percutaneous coronary intervention (PPCI). Pharmacol Res Perspect 9 : e00738.
Suzuki E, Matsunaga T, Aonuma A, Sasaki T, Nagata K, Ohmori S (2012). Effects of hypoxia-inducible factor-1α chemical stabilizer, CoCl(2) and hypoxia on gene expression of CYP3As in human fetal liver cells.Drug Metab Pharmacokinet 27 : 398-404.
Suzuki S, Oguro A, Osada-Oka M, Funae Y, Imaoka S (2008). Epoxyeicosatrienoic acids and/or their metabolites promote hypoxic response of cells. J Pharmacol Sci 108 : 79-88.
Takano H, Yamaguchi JI, Kato S, Hamada M, Tada M, Endo H (2021). Downregulation of CYP1A2, CYP2B6, and CYP3A4 in human hepatocytes by prolyl hydroxylase domain 2 inhibitors via hypoxia-inducible factor-α stabilization. Drug Metab Dispos 49 : 20-30.
Tantawy M, Collins JM, Wang D (2022). Genome-wide microRNA profiles identify miR-107 as a top miRNA associating with expression of the CYP3As and other drug metabolizing cytochrome P450 enzymes in the liver.Front Pharmacol 13 : 943538.
Toda T, Saito N, Ikarashi N, Ito K, Yamamoto M, Ishige A et al. (2009). Intestinal flora induces the expression of Cyp3a in the mouse liver.Xenobiotica 39 : 323-334.
Togao M, Tajima S, Kurakawa T, Wagai G, Otsuka J, Kado S et al. (2021). Normal variation of the gut microbiota affects hepatic cytochrome P450 activity in mice. Pharmacol Res Perspect 9 : e00893.
Vafeas C, Mieyal PA, Urbano F, Falck JR, Chauhan K, Berman M et al. (1998). Hypoxia stimulates the synthesis of cytochrome P450-derived inflammatory eicosanoids in rabbit corneal epithelium. J Pharmacol Exp Ther 287 : 903-910.
Valencia-Cervantes J, Huerta-Yepez S, Aquino-Jarquín G, Rodríguez-Enríquez S, Martínez-Fong D, Arias-Montaño JA et al. (2019). Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia‑inducible factor 1α‑mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation.Oncol Rep 41 : 178-190.
van Malenstein H, Verslype C, Windmolders P, van Eijsden R, Nevens F, van Pelt J (2012). Characterization of a cell culture model for clinically aggressive hepatocellular carcinoma induced by chronic hypoxia. Cancer Lett 315 : 178-188.
Velenosi TJ, Feere DA, Sohi G, Hardy DB, Urquhart BL (2014). Decreased nuclear receptor activity and epigenetic modulation associates with down-regulation of hepatic drug-metabolizing enzymes in chronic kidney disease. Faseb j 28 :5388-5397.
Vij AG, Kishore K, Dey J (2012). Effect of intermittent hypobaric hypoxia on efficacy & clearance of drugs. Indian J Med Res 135 : 211-216.
Vorrink SU, Severson PL, Kulak MV, Futscher BW, Domann FE (2014). Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Toxicol Appl Pharmacol 274 : 408-416.
Wang C, Jia Z, Li W, Lu H, Luo B, Liu J et al. (2017). UFLC-MS/MS assay for pharmacokinetics of levofloxacin in rats after acute ascent to high altitude. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong 46 : 160-64.
Wang JS, Cheng ML, Yen HC, Lou BS, Liu HC (2009). Vitamin E suppresses enhancement of factor VIII-dependent thrombin generation by systemic hypoxia. Stroke 40 : 656-659.
Wang R, Sun Y, Yin Q, Xie H, Li W, Wang C et al. (2017). The effects of metronidazole on Cytochrome P450 Activity and Expression in rats after acute exposure to high altitude of 4300m. Biomed Pharmacother85 : 296-302.
Wang S, Wei Y, Hu C, Liu F (2022). Proteomic analysis reveals proteins and pathways associated with declined testosterone production in male obese mice after chronic high-altitude exposure. Front Endocrinol (Lausanne) 13 : 1046901.
Wang Y, Fang ZH, Hong M, Yang D, Xie W (2020). Long-noncoding RNAs (lncRNAs) in drug metabolism and disposition, implications in cancer chemo-resistance. Acta Pharmaceutica Sinica B 10 : 105-112.
Wenbin L, Rong W, Hua X, Juanhong Z, Xiaoyu W, Zhengping J (2015). Effects on pharmacokinetics of propranolol and other factors in rats after acute exposure to high altitude at 4,010 m. Cell Biochem Biophys 72 : 27-36.
White K, Loughlin L, Maqbool Z, Nilsen M, McClure J, Dempsie Y et al. (2011). Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH. Physiol Genomics 43 : 417-437.
Xie Y (2021). Effects of plateau hypoxia and intestinalmicroorganisms on the metabolism ofmetoprolol and metronidazol. Lanzhou University .
Xin JW, Chai ZX, Zhang CF, Zhang Q, Zhu Y, Cao HW et al. (2022). Differences in proteomic profiles between yak and three cattle strains provide insights into molecular mechanisms underlying high-altitude adaptation. J Anim Physiol Anim Nutr (Berl) 106 : 485-493.
Xu J, Yang YZ, Tang F, Ga Q, Wuren T, Wang Z et al. (2015). CYP17A1 and CYP2E1 variants associated with high altitude polycythemia in Tibetans at the Qinghai-Tibetan Plateau. Gene 566 : 257-263.
Yan L, Wang Y, Liu J, Nie Y, Zhong XB, Kan Q et al. (2017). Alterations of histone modifications contribute to pregnane X receptor-mediated induction of CYP3A4 by rifampicin. Mol Pharmacol 92 : 113-123.
Yang J, Bai X, Liu G, Li X (2022). A transcriptional regulatory network of HNF4α and HNF1α involved in human diseases and drug metabolism.Drug Metab Rev 54 : 361-385.
Yu H, Shao H, Wu Q, Sun X, Li L, Li K et al. (2017). Altered gene expression of hepatic cytochrome P450 in a rat model of intermittent hypoxia with emphysema. Mol Med Rep 16 : 881-886.
Yu L, Chen Y, Wang W, Xiao Z, Hong Y (2016). Multi-vitamin B supplementation reverses hypoxia-induced tau hyperphosphorylation and improves memory function in adult mice. J Alzheimers Dis54 : 297-306.
Yu M, Liu X, Li J (2020). Factors influencing vitamin D levels inneonatal umbilical cord blood: a two-center study from tibet and shenyang. Front Pediatr 8 : 543719.
Yuan X, Xiang D, Min Q, Ding Y, Zhao A, Wang R (2019). Effects of acute hypoxia on expression of pregnane X receptor in liver tissues of rats exposed to high altitude. Zhejiang Da Xue Xue Bao Yi Xue Ban48 : 603-608.
Zhang J (2013). Foundational research on the effect of pharmacokinetics of drugs at high altitude environment. Lanzhou University .
Zhang J, Sun Y, He , Wu G, Wang R, Zhang J (2023). Comprehensive investigation of the influence of high-altitude hypoxia on clopidogrel metabolism and gut microbiota. Curr Drug Metab 24 : 723-733.
Zhang J, Wang R, Xie H, Yin Q, Jia Z, Li W (2014). Effect of acute exposure to high altitude on pharmacokinetics of propranolol and metoprolol in rats. Nan Fang Yi Ke Da Xue Xue Bao 34 : 1616-1620.
Zhang J, Xiang D, Wang R, Xie H, Yin Q, Jia Z et al. (2013). Comparative study on pharmacokinetics of mosapride in different environmental conditions in rats. Medical & Pharmaceutical Journal of Chinese People’s Liberation Army 25 : 24-27.
Zhang J, Xiong Q, Yang L, Xue Y, Ke M, Li Z (2021). Cytochrome P450 2J2 inhibits the proliferation and angiogenesis of retinal vascular endothelial cells by regulating the Notch signaling pathway in a hypoxia-induced retinopathy model. Bioengineered 12 : 10878-10890.
Zhang J, Zhu J, Yao X, Duan Y, Zhou X, Yang M et al. (2016). Pharmacokinetics of lidocaine hydrochloride metabolized by CYP3A4 in Chinese han volunteers living at low altitude and in native han and tibetan Chinese volunteers living at high altitude. Pharmacology97 :107-113.
Zhang N, Walker MK (2007). Crosstalk between the aryl hydrocarbon receptor and hypoxia on the constitutive expression of cytochrome P4501A1 mRNA. Cardiovasc Toxicol 7 : 282-290.
Zhang P, Chen JS, Li QY, Sheng LX, Gao YX, Lu BZ et al. (2020). Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys. Zool Res 41 : 3-19.
Zhang R, Gesangluob, Huang J, Cibai, Suonayangzong, Cirenzhuoma (2023). Study on pharmacokinetic characteristics of amlodipine besylate among Tibetan healthy human body living in plateau. China Medicine 18 : 1381-85.
Zhang S, Fu W, Jia X, Bade R, Liu X, Xie Y et al. (2023). Hypoxic preconditioning modulates BDNF and its signaling through DNA methylation to promote learning and memory in mice. ACS Chem Neurosci14 : 2320-2332.
Zhang W, Jiao L, Liu R, Zhang Y, Ji Q, Zhang H et al. (2018). The effect of exposure to high altitude and low oxygen on intestinal microbial communities in mice. PLoS One 13 : e0203701.
Zhang X, Huang L, Mou H, Wang R (2023). Effects of acute exposure to high altitude on pharmacokinetic parameters of miglitol in rats.Military Medicine of Joint Logistics 37 : 643-46+02.
Zhang Y, Yan T, Wang T, Liu X, Hamada K, Sun D et al. (2022). Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity. Acta Pharm Sin B 12 : 2224-2238.
Zhao MZ, Ma JS, Li M, Zhang YT, Jiang BX, Zhao XL et al. (2021). Cytochrome P450 enzymes and drug metabolism in humans.International Journal of Molecular Sciences 22 : 12808.
Zhao Q, Huang J, Wang D, Chen L, Sun D, Zhao C (2018). Endothelium-specific CYP2J2 overexpression improves cardiac dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling. J Mol Cell Cardiol 123: 118-127.
Zhou Y, Zhu J, Duan Y, Yang J, Bai X, Liu G, et al (2021). Effects of high altitude hypoxia on the pharmacokinetics of losartan potassium.Journal of Chinese High Altitude Medicine and Biology 42 : 223-33.
Zhu D, Huang J, Gu X, Li L, Han J (2021). Downregulation of aromatase plays a dual role in preeclampsia. Mol Hum Reprod 27 : gaab013.
Zhu D, Medhora M, Campbell WB, Spitzbarth N, Baker JE, Jacobs ER (2003). Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries. Circ Res 92 : 992-1000.
Zhu J, Duan Y, Duo D, Yang J, Bai X, Liu G et al. (2022). High-altitude hypoxia influences the activities of the drug-metabolizing enzyme CYP3A1 and the pharmacokinetics of four cardiovascular system drugs.Pharmaceuticals (Basel) 15 .
Zhu JB, Yang JX, Nian YQ, Liu GQ, Duan YB, Bai X et al. (2021). Pharmacokinetics of acetaminophen and metformin hydrochloride in rats after exposure to simulated high altitude hypoxia. Front Pharmacol12 : 692349.