1 Introduction
Subacute combined degeneration (SCD) is a neurodegenerative
demyelinating disease that affects the posterior and lateral columns of
the cervical and upper dorsal parts of the spinal cord and is caused
primarily by vitamin B12 deficiency. In addition to SCD, vitamin B12
deficiency produces various other neurological and psychiatric symptoms
as well as a wide spectrum of hematological abnormalities [1].
Chronic vitamin B12 deficiency has been identified in the majority of
patients with hyperhomocysteinaemia (HHcy), which promotes venous
thrombosis and atherosclerosis via various mechanisms [2]. One such
case report of a young patient demonstrated severe HHcy secondary to
vitamin B12 deficiency as a cause of pulmonary embolism and myocardial
infarction [3]. Although the association of deep venous thrombosis
with HHcy has been well established [4, 5], its presentation with
SCD is not reported in literature to our best of knowledge. The current
report describes a 68 years old female who presented with SCD of the
spinal cord coexisting with deep venous thrombosis (DVT).