Association of corticosteroid inhaler type with saliva
microbiome in moderate-to-severe pediatric asthma
Amir Hossein Alizadeh Bahmani1, 2, 3, Mahmoud I.
Abdel-Aziz1, 2, 3, Simone Hashimoto1,
4, Corinna Bang5, Susanne
Brandstetter6, Paula
Corcuera-Elosegui7, Andre Franke5,
Mario Gorenjak8, Susanne Harner9,
Parastoo Kheiroddin9, , Leyre
López-Fernández7, Anne H. Neerincx1,
Maria Pino-Yanes10, 11, 12, Uroš
Potočnik8, Olaia Sardón-Prado7, 13,
Antoaneta A. Toncheva9, Christine
Wolff9, Michael Kabesch9, Aletta D.
Kraneveld14, Susanne J.H.
Vijverberg1, 2, 3, Anke H. Maitland-van der
Zee1, 2, 3, on behalf of the SysPharmPediA consortium
1 Department of Pulmonary Medicine, Amsterdam UMC
location University of Amsterdam, Meibergdreef 9, Amsterdam, the
Netherlands.
2 Amsterdam institute for Infection and Immunity,
Inflammatory diseases, Amsterdam, the Netherlands.
3 Amsterdam Public Health, Personalized Medicine,
Amsterdam, The Netherlands.
4 Department of Pediatric Pulmonology and Allergy,
Emma Children’s Hospital, Amsterdam University Medical Center,
Amsterdam, The Netherlands.
5 Institute of Clinical Molecular Biology,
Christian-Albrechts-University of Kiel, Kiel, Germany.
6 University Children’s Hospital Regensburg (KUNO),
University of Regensburg, Regensburg, Germany.
7 Division of Pediatric Respiratory Medicine, Hospital
Universitario Donostia, San Sebastia ̵́n, Spain.
8 Center for Human Molecular Genetics and
Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor,
Slovenia.
9 Department of Pediatric Pneumology and Allergy,
University Children’s Hospital Regensburg (KUNO), Regensburg, Germany.
10 Genomics and Health Group, Department of
Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La
Laguna (ULL), Santa Cruz de Tenerife, Spain.
11 CIBER de Enfermedades Respiratorias, Instituto de
Salud Carlos III, Madrid, Spain.
12 Instituto de Tecnologías Biomédicas (ITB),
Universidad de La Laguna (ULL), La Laguna, Spain.
13 Department of Pediatrics. School of Medicine and
Nursery. University of te Basque Country, San Sebastián, Spain.
14 Division of Pharmacology, Utrecht Institute for
Pharmaceutical Sciences, Faculty of Science, Utrecht University,
Universiteitsweg 99, Utrecht 3584 CG, the Netherlands.
Abstract