Conclusion
Types of ICS devices are associated with different saliva microbiome composition in moderate-to-severe pediatric asthma. The causal relation between inhaler types and changes in saliva microbiota composition needs to be further evaluated, as well as whether this leads to different potential adverse effects in terms of occurrence and level of severity.
Keywords: Asthma, Inhaled Corticosteroids, Metered Dose Inhaler, Dry Powder Inhaler, Microbiome, Saliva