Association of corticosteroid inhaler type with saliva microbiome in moderate-to-severe pediatric asthma
Amir Hossein Alizadeh Bahmani1, 2, 3, Mahmoud I. Abdel-Aziz1, 2, 3, Simone Hashimoto1, 4, Corinna Bang5, Susanne Brandstetter6, Paula Corcuera-Elosegui7, Andre Franke5, Mario Gorenjak8, Susanne Harner9, Parastoo Kheiroddin9, , Leyre López-Fernández7, Anne H. Neerincx1, Maria Pino-Yanes10, 11, 12, Uroš Potočnik8, Olaia Sardón-Prado7, 13, Antoaneta A. Toncheva9, Christine Wolff9, Michael Kabesch9, Aletta D. Kraneveld14, Susanne J.H. Vijverberg1, 2, 3, Anke H. Maitland-van der Zee1, 2, 3, on behalf of the SysPharmPediA consortium
1 Department of Pulmonary Medicine, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.
2 Amsterdam institute for Infection and Immunity, Inflammatory diseases, Amsterdam, the Netherlands.
3 Amsterdam Public Health, Personalized Medicine, Amsterdam, The Netherlands.
4 Department of Pediatric Pulmonology and Allergy, Emma Children’s Hospital, Amsterdam University Medical Center, Amsterdam, The Netherlands.
5 Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
6 University Children’s Hospital Regensburg (KUNO), University of Regensburg, Regensburg, Germany.
7 Division of Pediatric Respiratory Medicine, Hospital Universitario Donostia, San Sebastia ̵́n, Spain.
8 Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
9 Department of Pediatric Pneumology and Allergy, University Children’s Hospital Regensburg (KUNO), Regensburg, Germany.
10 Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), Santa Cruz de Tenerife, Spain.
11 CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
12 Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna (ULL), La Laguna, Spain.
13 Department of Pediatrics. School of Medicine and Nursery. University of te Basque Country, San Sebastián, Spain.
14 Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, Utrecht 3584 CG, the Netherlands.
Abstract