Conclusion
The findings of this study underscore the importance of considering
inhaler type as a potential factor influencing saliva microbiome
composition in children with moderate-to-severe asthma. Further research
is needed to elucidate the underlying mechanisms driving these
differences and to determine the clinical implications of altered
microbiome composition on asthma outcomes and oral health. Understanding
the impact of inhaler devices on microbiome composition and microbial
dysbiosis may ultimately inform personalized asthma management
strategies tailored to individual microbial profiles.