Term ID Term description Observed gene count Background gene count Strength Signal False discovery rate Matching proteins in the network
Biological Process
GO:0006805 Xenobiotic metabolic process 5 59 2.01 2.23 1.22E-05 CYP1A2, CYP1A1, AHR, CYP1B1, AHRR
Molecular Function
GO:0070330 Aromatase activity 3 13 2.44 1.58 0.00069 CYP1A2, CYP1A1, CYP1B1
Cellular Component
GO:0034751 Aryl hydrocarbon receptor complex 3 9 2.6 1.95 0.00013 AHR, ARNT, AHRR
Local Network Cluster (STRING)
CL:3288 Steroid hormone biosynthesis 4 12 2.6 2.82 2.08E-06 CYP1A2, UGT1A1, CYP1A1, LOC769841
CL:24010 Mixed, incl. Ubiquitin family, and WWE domain, subgroup 2 5 2.68 1.12 0.0064 TIPARP, AHRR
CL:3291 Atorvastatin ADME, and Cytochrome P450, E-class, group I, CYP1 2 5 2.68 1.12 0.0064 UGT1A1 ,CYP1A1
CL:3302 Mixed, incl. Response to mycotoxin, and Cytochrome P450, E-class, group I, CYP2D-like 2 5 2.68 1.12 0.0064 CYP1A2, LOC769841
CL:19140 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain), and Peptidyl-proline 4-dioxygenase activity 2 15 2.2 0.78 0.0276 AHR, ARNT
KEGG Pathways
gga00140 Steroid hormone biosynthesis 5 30 2.3 3.72 9.57E-09 CYP1A2, UGT1A1, CYP1A1, CYP1B1, LOC769841
gga00980 Metabolism of xenobiotics by cytochrome P450 4 29 2.22 2.81 1.01E-06 CYP1A2, UGT1A1, CYP1A1, CYP1B1
gga00380 Tryptophan metabolism 3 36 2 1.7 0.00023 CYP1A2, CYP1A1, CYP1B1
gga00830 Retinol metabolism 3 36 2 1.7 0.00023 CYP1A2, UGT1A1, CYP1A1
gga00860 Porphyrin and chlorophyll metabolism 2 21 2.06 1.11 0.0054 UGT1A1, ALAS1
Reactome Pathways
GGA-211859 Biological oxidations 6 126 1.76 2.39 9.53E-07 UGT1A1, AHR, CYP1B1, LOC769841, ARNT, AHRR
GGA-211976 Endogenous sterols 4 18 2.43 2.8 1.74E-06 AHR, CYP1B1, ARNT, AHRR
GGA-8937144 Aryl hydrocarbon receptor signalling 3 5 2.86 2.53 1.02E-05 AHR, ARNT, AHRR
GGA-211981 Xenobiotics 3 11 2.51 2.13 5.21E-05 AHR, ARNT, AHRR
GGA-9753281 Paracetamol ADME 2 18 2.12 0.78 0.0276 UGT1A1, LOC769841
Subcellular Localization
GOCC:0034751 Aryl hydrocarbon receptor complex 3 9 2.6 1.91 0.00016 AHR, CYP1B1, ARNT
Protein Domain and Features
PF00067 Cytochrome P450 3 47 1.88 0.85 0.0174 CYP1A2, CYP1A1, CYP1B1
IPR008066 Cytochrome P450, E-class, group I, CYP1 2 2 3.08 1 0.0116 CYP1A2, CYP1A1
SM00091 PAS domain 3 29 2.09 1.35 0.0017 AHR, ARNT, AHRR
SM00353 Helix loop helix domain 3 102 1.55 0.7 0.0306 AHR, ARNT, AHRR