RESULTS

A. Target tissue exposure

The results from multiphoton imaging are represented in Figure 2. The visual analysis of the fluorescence intensity indicated that liver tissue in the group that received injections with a fluorescent dye, acridine orange demonstrated an increase in fluorescent staining compared to control group which received injections with deionized water only (Figure 2). This confirms sufficient liver uptake of acridine orange which has reached the target tissue following its administration into the air sac.