Key Clinical Message
In the majority of cases, patients with multiple myeloma (MM) generally
exhibit normal or decreased blood lipid levels. However, a minority of
cases demonstrate the significant role of M protein in elevated lipid
levels, particularly in the close association between IgA type MM and
hypertriglyceridemia and hypercholesterolemia. Here, we report a case of
IgA-κ type MM with concurrent hyperlipidemia, wherein the patient
presented with elevated lipid levels upon admission: total cholesterol
of 10.44 mmol/L (normal range: 2.8-5.6 mmol/L) and triglycerides of
28.45 mmol/L (normal range: 0.45-1.70 mmol/L). The patient also had
concurrent multiple myeloma and was treated with the PCD regimen along
with lipid-lowering measures, hydration, alkalization, liver protection,
and symptomatic supportive care, who showed a significant improvement in
symptoms and was discharged. This report discusses a case treated at the
Second Affiliated Hospital of Henan University of Science and
Technology, retrospectively summarizing and analyzing the patient’s
data, and, in conjunction with relevant literature, explores the
relationship between IgA type MM and hyperlipidemia. The aim is to
provide guidance for clinical diagnosis and treatment.