1.Introduction
Multiple myeloma is characterized by the clonal proliferation of
malignant plasma cells in the bone marrow, accompanied by the excessive
production of monoclonal immunoglobulins or light chains (M
protein)[1, 2]. The malignant proliferation of plasma cells and
abnormal levels of immunoglobulins lead to clinical symptoms
characterized by CRAB, namely C: hypercalcemia, R: renal impairment, A:
anemia, and B: bone pain, skeletal changes, or pathological
fractures[3]. Depending on the type of immunoglobulin secreted by
the abnormal myeloma cells, MM can be classified into eight types: IgG,
IgA, IgM, IgD, IgE, biclonal, non-secretory, and light chain (κ, λ)[4,
5].
The majority of MM patients exhibit normal or decreased blood lipid
levels. However, isolated cases have reported the significant role of M
protein in elevated lipid levels[6-8]. Among these cases, IgA type
multiple myeloma is particularly associated with hypertriglyceridemia
and hypercholesterolemia.