Introduction
Pemphigus vulgaris (PV) and eosinophilic esophagitis (EoE) are
autoimmune and immune-mediated disorders, respectively, that impact
distinct organ systems1,2. PV is characterized by the
presence of autoantibodies targeting desmogleins, leading to skin and
mucosal blistering1. EoE, on the other hand, involves
eosinophilic infiltration of the esophageal epithelium, typically
associated with allergic conditions2. The concurrent
presentation of PV and EoE is rare and poses significant diagnostic
challenges3. This report examines two cases where
patients experienced both conditions, highlighting the need for careful
differentiation between esophageal involvement by PV and EoE. These
cases illustrate the importance of thorough diagnostic workup, including
endoscopy and biopsy, to ensure accurate diagnosis and effective
treatment.