Introduction
Pemphigus vulgaris (PV) and eosinophilic esophagitis (EoE) are autoimmune and immune-mediated disorders, respectively, that impact distinct organ systems1,2. PV is characterized by the presence of autoantibodies targeting desmogleins, leading to skin and mucosal blistering1. EoE, on the other hand, involves eosinophilic infiltration of the esophageal epithelium, typically associated with allergic conditions2. The concurrent presentation of PV and EoE is rare and poses significant diagnostic challenges3. This report examines two cases where patients experienced both conditions, highlighting the need for careful differentiation between esophageal involvement by PV and EoE. These cases illustrate the importance of thorough diagnostic workup, including endoscopy and biopsy, to ensure accurate diagnosis and effective treatment.