3.5 Metabolism of 89Zr-IP150 in KM Mice
and Radiation Dose Estimation
As shown in Supplementary Figure 1D-F, the micro-PET/CT imaging results
showed that 89Zr-IP150 was metabolized by the liver in
KM mice from 2 to 120 hours post injection. The signal of89Zr-IP150 was clearly visible in the blood pool at 2
hours, the SUVmax was 0.90±0.09 and then gradually decreased, and the
SUVmax was only 0.44±0.02 at 120 hours. In addition,89Zr-IP150 also had high uptake in the spleen, but the
uptake decreased gradually from 2 to 120 hours (0.80±0.05 to 0.48±0.03).
The uptake of 89Zr-IP150 in other normal organs
(lungs, muscle, bone, and brain) was minimal.
Then, the human organ radiation dosimetry estimation of89Zr-IP150 in adult female patients was calculated. As
shown in Table 2, the organ predicted to have the highest absorbed dose
in humans was the liver (0.218 mGy/MBq), followed by the spleen (0.211
mGy/MBq) and lung (0.195 mGy/MBq). The effective dose was 0.065 mSv/MBq,
indicating that when a person injected 37 MBq89Zr-IP150, the radiation dose received was 2.41 mSv,
which is acceptable for routine nuclear medicine research.
Table 2. Human Organ Radiation Dosimetry Estimation of89Zr-IP150 in Adult Female Patients Using OLINDA/EXM
1.0