Figure 3 . (A) Micro-PET/CT images of A375 tumor-bearing mice after administration of 89Zr-IP150 (n = 3/group). (B) IHC staining of MUC18 in tumors. Scale bar = 50 μm.
Further analysis revealed that the tumor uptake of89Zr-IP150 at 24 h (R2 = 0.9543,p = 0.0231), 72 h (R2 = 0.9379, p = 0.0316), and the peak timepoint (R2 = 0.9460,p = 0.0274) correlated with the expression levels of MUC18 in A375, HMVII, SK-Mel-28, and A549 cells (Figure 4C).