Figure 2. (A) Scheme of 89Zr-labeled IP150.(B), (C) Average molecular weights of IP150 and DFO-IP150.(D) The radiochemical purity of unpurified89Zr-IP150. (E) The binding ability of IP150
and DFO-IP150 to the MUC18 protein. (F) (G) Protein expression
levels of MUC18 in different cancer cell lines. (H) Receptor
binding assay of 89Zr-IP150 in the A375 cell line.(I) Cellular uptake of 89Zr-IP150 in A375,
SK-Mel-28 (cutaneous melanoma), and HMVII (mucosal melanoma) cells.(J) Comparison of the uptake in four cell lines at 240 min.
***, p < 0.001; ****, p < 0.0001.