The effect of HCQ on platelet counts
To analyze the effect of HCQ on platelet counts in chronic ITP children
in the context of combined therapy, we conducted mixed-effect models
(Table 3). Results showed that HCQ was associated with increased
platelet counts, which was supported by the significant main effect of
HCQ from the mixed-effects model with adjustment for confounding factors
(mean difference of platelet counts between HCQ and non-HCQ groups:
23.82×109/L; 95% CI: 7.44 ~ 40.21).
Besides, the insignificant interaction term from the mixed-effects model
did not support the existence of correlation between the baseline ANA
positivity and HCQ treatment effectiveness. The sensitivity analysis
yielded similar estimates (Table S1).