HCQ, hydroxychloroquine; SD, standard deviation; ANA, antinuclear antibody; R, response; CR, complete response; NA, not available; IVIG, intravenous immunoglobulin; TPO-RA, thrombopoietin receptor agonist.
* Symptoms associated with autoimmune diseases included joint pain, rash, alopecia, ulceration, Raynaud’s phenomenon, and so on, which were identified by rheumatologists.
Positive antiphospholipid antibodies include lupus anticoagulant, anti-β2-glycoprotein I antibody (IgG/IgM), and anticardiolipin antibody (IgG/IgM).
Seven patients initially diagnosed with ITP progressed to SLE during the course. All of them had symptoms or positive markers associated with autoimmune diseases, but none of them met the criteria of SLE diagnosis when they diagnosed as ITP.
Table 3 Results of a mixed-effects model in platelet counts.