Efficacy of quercetin-loaded exosomes from mare’s milk
compared to free quercetin in an aging male rat model
The efficiency of quercetin-loaded exosomes derived from mare’s milk
versus free quercetin were evaluated using an aging model of male Wistar
outbred rats. Experimental groups consisted of males older than 12
months, with young male Wistar rats aged 8 weeks serving as the negative
control. On average, the rats weighted 200 ± 20 g and housed in the
animal facility of the National Center for Biotechnology, Astana,
Kazakhstan. After one-week adaptation period, the rats were randomly
divided into their groups (3 rats/cage) and housed in a room with
controlled temperature and a 12-h light–dark cycle with unlimited
access to standard food and drinking water ad libitum.