All of the exosomes only group, showed hyperplasia of tubular epitheliocytes, formation of protein casts, presence of lymphoid infiltrates in the renal interstitium, but no tubular vacuolization (Figure 8). Sections stained with Periodic Acid-Schiff (PAS) revealed thickening and fibrosis of the glomerular basal membranes and glomerulosclerosis in all animals (Table 2). Notably, pronounced eosinophilic infiltration in the kidney capsule was observed in all animals (Table 2), but focal hyalinosis was observed in two animals only (Table 2).