Interestingly, animals in the quercetin loaded exosomes, showed no tubular epithelial vacuolization, but two animals, showed hyperplasia of tubular epitheliocytes, focal cellular infiltration in the renal interstitium, predominantly consisting of lymphatic and plasma cells, thickening and fibrosis of glomerular membranes and focal hyalinosis (Table 2). Formation of protein casts, glomerulosclerosis, and eosinophilic infiltration were observed in the kidney capsules of all 3 animals (Table 2).