Graphical Abstract
Line-field Confocal Optical Coherence Tomography (LC-OCT) is used to
determine the human skin in vivo optical properties modifications
caused by biocompatible optical clearing. After a prior calibration
using a phantom with determined optical properties, a theoretical model
is applied to mean in-depth intensity profiles of 3D LC-OCT images
acquired during optical clearing protocol. As a result, kinetic relative
changes of epidermal and dermal layer optical properties demonstrated
with the best results caused by the mixture of Polyethylene Glycol,
Oleic Acid and Propylene Glycol.