(a) 3D LC-OCT image of human skin in vivo , represented in slice view and (b) averaged intensity profile R (z ), showing mean linear regression fit of each skin layer (epidermis – red, dermis – blue) and a corresponding pairs of observables (\(\rho^{\text{epi}},\ µ_{\text{eff}}^{\text{epi}}\) and\(\rho^{\text{der}},\ µ_{\text{eff}}^{\text{der}}\)). Dermal layer parameter ρ der deduced from the intercept with basal membrane (z = ~150 µm) and corrected from epidermal layer attenuation.
Keywords: modelling; optical clearing; optical coherence tomography; optical properties, scattering; skin
Abbreviations: CPE , chemical permeation enhancer;DMSO , dimethyl sulfoxide; LC-OCT , Line-field Optical Coherence Tomography; OA , oleic acid; OC , optical clearing; OCA , optical clearing agent; OCT , Optical Coherence Tomography; PEG , polyethylene glycol; PG , propylene glycol; RI , refractive index; SC , stratum corneum;