2.3 In vivo human skin sites
The experimental skin sites were the left and right hand thenar space
dorsum of three healthy volunteers aged around 28 years with skin
phototypes 2 and 3. An informed consent was obtained from the volunteers
for topical OCA application, dermabrasion and sonophoretic treatment of
experimental skin sites and the acquisition of 3D LC-OCT images.
Volunteers’ safety was guaranteed by FDA-approved concentrations of OCAs
and by CE-marked LC-OCT, dermabrasion and sonophoresis medical devices.
Since the dataset used in a current study had been acquired for the
previously performed research,[26] an
authorization for the human skin studies in vivo was obtained
from the Saratov State Medical University Ethical committee (protocol
â„–11 by June 7th 2022).