2.3 In vivo human skin sites
The experimental skin sites were the left and right hand thenar space dorsum of three healthy volunteers aged around 28 years with skin phototypes 2 and 3. An informed consent was obtained from the volunteers for topical OCA application, dermabrasion and sonophoretic treatment of experimental skin sites and the acquisition of 3D LC-OCT images. Volunteers’ safety was guaranteed by FDA-approved concentrations of OCAs and by CE-marked LC-OCT, dermabrasion and sonophoresis medical devices. Since the dataset used in a current study had been acquired for the previously performed research,[26] an authorization for the human skin studies in vivo was obtained from the Saratov State Medical University Ethical committee (protocol №11 by June 7th 2022).