(a) 3D LC-OCT image of human skin in vivo , represented in slice
view and (b) averaged intensity profile R (z ), showing mean
linear regression fit of each skin layer (epidermis – red, dermis –
blue) and a corresponding pairs of observables
(\(\rho^{\text{epi}},\ µ_{\text{eff}}^{\text{epi}}\) and\(\rho^{\text{der}},\ µ_{\text{eff}}^{\text{der}}\)). Dermal layer
parameter ρ der deduced from the intercept with
basal membrane (z = ~150 µm) and corrected from
epidermal layer attenuation.
Keywords: modelling; optical clearing; optical coherence
tomography; optical properties, scattering; skin
Abbreviations: CPE , chemical permeation enhancer;DMSO , dimethyl sulfoxide; LC-OCT , Line-field Optical
Coherence Tomography; OA , oleic acid; OC , optical
clearing; OCA , optical clearing agent; OCT , Optical
Coherence Tomography; PEG , polyethylene glycol; PG ,
propylene glycol; RI , refractive index; SC , stratum
corneum;