Key clinical message
Xeroderma Pigmentosum significantly increases the risk of developing
skin and internal malignancies, with rare associations such as spindle
cell carcinoma. Patients with XP may present with atypical symptoms like
cough, haemoptysis, and shortness of breath, which should prompt further
investigation for potential malignancies. Additionally, neurological
symptoms like focal seizures can occur alongside malignancies,
complicating the clinical presentation and management. Early detection
and treatment are crucial, but in advanced cases, palliative care may be
necessary due to limited treatment options and the progressive nature of
the disease.