ABSTRACT

Xeroderma Pigmentosum is a rare autosomal recessive disorder characterized by UV sensitivity, leading to skin malignancies, ophthalmologic issues, and neurological symptoms. Few cases have reported its association with lung cancer. A 22-year-old male with Xeroderma Pigmentosum presented with a 6-month history of non-productive cough, haemoptysis, fever, and shortness of breath. Examination revealed cervical lymphadenopathy, hypo- and hyperpigmented macules, and focal seizures. Blood tests indicated elevated leukocytes, ESR, and alkaline phosphatase. Imaging and biopsy confirmed spindle cell carcinoma. Neurological evaluation diagnosed focal seizures, managed with carbamazepine. Palliative care was chosen due to advanced cancer. This is the first documented case linking XP with spindle cell carcinoma and focal seizures. Palliative care was chosen due to disease progression and financial condition.