ABSTRACT
Xeroderma Pigmentosum is a rare autosomal recessive disorder
characterized by UV sensitivity, leading to skin malignancies,
ophthalmologic issues, and neurological symptoms. Few cases have
reported its association with lung cancer. A 22-year-old male with
Xeroderma Pigmentosum presented with a 6-month history of non-productive
cough, haemoptysis, fever, and shortness of breath. Examination revealed
cervical lymphadenopathy, hypo- and hyperpigmented macules, and focal
seizures. Blood tests indicated elevated leukocytes, ESR, and alkaline
phosphatase. Imaging and biopsy confirmed spindle cell carcinoma.
Neurological evaluation diagnosed focal seizures, managed with
carbamazepine. Palliative care was chosen due to advanced cancer. This
is the first documented case linking XP with spindle cell carcinoma and
focal seizures. Palliative care was chosen due to disease progression
and financial condition.