Introduction
Xeroderma Pigmentosum is an uncommon genetic condition that is
characterized by sensitivity to ultraviolet rays, ultimately leading to
severe sunburn reactions and increased risk of skin cancer (1). Patients
require stringent photoprotection measures, including sunscreen
application and protective clothing (2). The clinical manifestations
include hypo and hyperpigmented macules, premature aging, sunburns,
blistering, and increased incidence of different malignancies in the
skin. It also affects the eye and central nervous system (3). Patients
involved in the eye can experience progressive blindness (6). A complex
relationship exists between Xeroderma Pigmentosum and other
malignancies, which is poorly understood (2). Priya and Janaki (2017)
reported rare cases of carcinoma of the esophagus associated with
xeroderma pigmentosum (4). Though susceptible to different cancers, few
cases have been reported till now due to its rare nature (5). There is
an association with neurological symptoms in 20 % of cases (6).
Herein, we present the case of a 22-year-old male diagnosed with
Xeroderma Pigmentosum who developed Spindle Cell Carcinoma and
experienced focal seizures. This case report is the first documented
case associating Xeroderma Pigmentosum, Spindle Cell Carcinoma, and
focal seizures.