not-yet-known not-yet-known not-yet-known unknown 4.4. Th17 in hypertension Primary hypertension is a cardiovascular syndrome with the main clinical manifestation of elevated body circulating arterial pressure.. IL-17 and IL-6 secreted by the Th17 cells promoted a renal and vascular dysfunction and damage, which resulted in the increased water-sodium retention and systemic vascular resistance, further exacerbating the development of hypertension[57]. It was found that the activation of Th1 and Th17 cells could inhibit angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor antagonists (ARB)[58]. Antigen-specific T-cell activation is also facilitated by inhibiting the nuclear transcription factor (NF)-κB1 and promoting activation of the NF-κB2 pathway. In addition, studies have shown that the differentiation of Th17 cell in mice and humans can be stimulated by high salt, and increase the expression of IL-17A to drive autoimmunity, which may also help with high blood pressure[59].