Affiliations:
1 National Clinical Research Center for
Chinese Medicine Acupuncture and Moxibustion, State Key Laboratory of
Component-based Chinese Medicine, First Teaching Hospital of Tianjin
University of Traditional Chinese Medicine, Tianjin, China; State Key
Laboratory of Modern Chinese Medicine, Key Laboratory of Pharmacology of
Traditional Chinese Medical Formulae, Ministry of Education, Tianjin
University of Traditional Chinese Medicine, Tianjin, China.
*Corresponding authors: Lan Li: lilan_0813@163.com
Abstract: Recent research has shown a strong link between Th17
cells and their cytokine IL-17, and various cardiovascular diseases such
as myocarditis, myocardial infarction, and atherosclerosis. Moreover,
Th17 cell signalling is likely to be a key factor in cardiovascular
disease. Here, we summarize recent advances in the source, function,
regulation, and the effects of Th17 signaling in cardiovascular disease.
Research on Th17 will suggest more specific strategies to manipulate
these functions. Thus, effective treatment of cardiovascular disease and
future clinical treatment will be possible.
Significance Statement: Cardiovascular diseases pose a serious
threat to human health. And in recent years, cardiac immunotherapy has
shown great potential in the treatment of cardiovascular diseases. We
have explained in detail in this article the important role of Th17
cells, a type of immune cell, in cardiovascular disease. Regulating Th17
cells may become an effective therapeutic strategy for cardiovascular
diseases. In summary, we have summarized the latest advances in the
origin, function, regulation, and role of Th17 cells in cardiovascular
diseases.
Key words: Th17 · IL-17 · Immunity · Cardiovascular Disease