5. Conclusion
T helper 17 (Th17) cells, a subset of CD4+ T cells, are characterised by the secretion of interleukin-17A (IL-17A), IL-17F, IL-21, IL-22. Th17 and other IL-17-expressing T cells have recently emerged as crucial regulators of inflammatory responses in cardiovascular disease. Given this pathogenic potential, it is important to understand the mechanisms that promote Th17 differentiation. A large association study based on Th17 cells confirms their non-substitutable importance in cardiovascular disease. Th17 cells may promote heart failure by promoting ventricular remodeling. However, the specific mechanism of Th17 cells in cardiovascular disease is unclear, which provides new insights into their mechanisms and new targets for the diagnosis and treatment of cardiovascular disease. Experimental-based conclusions of Th17 cells, while the origin and developmental differentiation of the Th17 cell subgroup have certain differences in mice and humans, and the conclusions obtained in the mouse model cannot be completely equivalent to human clinical diseases, which remains to be further verified. Although there are still many related problems to be solved, the discovery and in-depth study of Th17 cells may further reveal the occurrence, development mechanisms of autoimmune diseases, and may potentially facilitate the discovery of new targets for the treatment of immune-related diseases.