Fig3. Signal transduction for the Th17:cytocytokines promoted the activation of the transcription factor RORγt through the activation of Stat3, SMADS and other pathways, thereby promoting Th17 cell differentiation. Inhabition of Th17:cytocytokines inhibited the activation of the transcription factor RORγt by inhibiting downstream proteins such as STAT5, STAT1, STAT6 (Foxp3, T-bet, GATA3, etc.), thereby inhibiting the differentiation of Th17 cells.