Affiliations:
1 National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, State Key Laboratory of Component-based Chinese Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China; State Key Laboratory of Modern Chinese Medicine, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
*Corresponding authors: Lan Li: lilan_0813@163.com
Abstract: Recent research has shown a strong link between Th17 cells and their cytokine IL-17, and various cardiovascular diseases such as myocarditis, myocardial infarction, and atherosclerosis. Moreover, Th17 cell signalling is likely to be a key factor in cardiovascular disease. Here, we summarize recent advances in the source, function, regulation, and the effects of Th17 signaling in cardiovascular disease. Research on Th17 will suggest more specific strategies to manipulate these functions. Thus, effective treatment of cardiovascular disease and future clinical treatment will be possible.
Significance Statement: Cardiovascular diseases pose a serious threat to human health. And in recent years, cardiac immunotherapy has shown great potential in the treatment of cardiovascular diseases. We have explained in detail in this article the important role of Th17 cells, a type of immune cell, in cardiovascular disease. Regulating Th17 cells may become an effective therapeutic strategy for cardiovascular diseases. In summary, we have summarized the latest advances in the origin, function, regulation, and role of Th17 cells in cardiovascular diseases.
Key words: Th17 · IL-17 · Immunity · Cardiovascular Disease