5. Conclusion
T helper 17 (Th17) cells, a subset of CD4+ T cells,
are characterised by the secretion of interleukin-17A (IL-17A), IL-17F,
IL-21, IL-22. Th17 and other IL-17-expressing T cells have recently
emerged as crucial regulators of inflammatory responses in
cardiovascular disease. Given this pathogenic potential, it is important
to understand the mechanisms that promote Th17 differentiation. A large
association study based on Th17 cells confirms their non-substitutable
importance in cardiovascular disease. Th17 cells may promote heart
failure by promoting ventricular remodeling. However, the specific
mechanism of Th17 cells in cardiovascular disease is unclear, which
provides new insights into their mechanisms and new targets for the
diagnosis and treatment of cardiovascular disease. Experimental-based
conclusions of Th17 cells, while the origin and developmental
differentiation of the Th17 cell subgroup have certain differences in
mice and humans, and the conclusions obtained in the mouse model cannot
be completely equivalent to human clinical diseases, which remains to be
further verified. Although there are still many related problems to be
solved, the discovery and in-depth study of Th17 cells may further
reveal the occurrence, development mechanisms of autoimmune diseases,
and may potentially facilitate the discovery of new targets for the
treatment of immune-related diseases.