Phagocytosis is a distinguished immunological process that assists the immune system in recognizing and responding effectively to eliminate foreign and self-pathogenic molecules. Improving the overall understanding of this immune mechanism during malaria infection is imperative. The full understanding of how this mechanism eradicates malaria parasites remains unclear, especially for Plasmodium falciparum. Which is an area requiring further broad investigations. In this context, previous studies have shown that various factors such as phagocyte cell subclasses, plasma protein molecules and Plasmodium evasion tactics influence the phagocytic process differently. However, the mechanisms underlying phagocytic activity during Plasmodium falciparum infection are still ambiguous. In this review, we aim to describe essential immunological aspects and the state of current knowledge on phagocytic activities in Plasmodium falciparum infection. We highlight the significant involvement of distinct active cells that induce phagocytosis. In addition, we discuss the implications and therapeutic approaches related to the effective phagocytic activity.