Mice
CB6F1 mice were ordered from Envigo (Horst, The Netherlands). Six–eight weeks-old female mice were used in all experiments. All mice were housed in the animal facilities at Statens Serum Institut, Denmark, and maintained in rooms with a controlled environment (20–23 ℃; relative humidity 55 ± 10 %; 12/12 h light/dark cycle). The mice were randomly allocated to conventional type III polycarbonate cages (820 cm2). All animals were provided Aspen bedding and bricks (Tapvei), EnviroDri (LBS), and polycarbonate tunnels or houses or DesRes paper houses (LBS). Irradiated sunflower seeds, corn grains, and peanuts or bits of carrots were given to the animals once a week. A pelleted diet (Envigo Teclad 2916) and tap water were provided ad libitum. Mouse studies were conducted following the regulations set forth by the National Animal Protection Committee and following European Community Directive 86/609. The governmental Animal Experiments Inspectorate has approved the experiments performed under licenses 2020-15-0201-00525.