not-yet-known not-yet-known not-yet-known unknown TABLE 1 Demographic and clinical data. FIGURE 3 Scatter plot demonstrating correlation between interval from neoadjuvant chemotherapy to surgery and tumor necrosis. Spearman’s correlation rho = -0.18, p = 0.096. FIGURE 4 Kaplan Meier curves of 5-year EFS based on interval from neoadjuvant chemotherapy completion to surgery, with different interval cut-offs. (A) Interval length > 14 days versus ≤ 14 days, p = 0.20. (B) Interval > 15 days versus ≤ 15 days, p = 0.14. (C) Interval length > 16 days versus ≤ 16 days, p = 0.019. (D) Interval length > 17 days versus ≤ 17 days, p = 0.014. FIGURE 5 Multivariable Cox regression with 5-year EFS hazard ratio. (A) Multivariable Cox regression of all patients with osteosarcoma in this study. (B) Forest plot demonstrating HR values of Figure 5A with 95% CI. (C) Multivariable Cox regression for patients with initially localized disease. (D) Forest plot demonstrating HR values of Figure 5C with 95% CI. Supplemental table 1 Multivariable linear regression of interval length and tumor necrosis .