1.Introduction:
Globally, the most common cause of viral hepatitis and a significant factor in end-stage liver disease is the hepatitis B virus (HBV) [1]. Approximately thirty million people are newly infected with HBV each year globally, and a total of 296 million people are currently living with chronic HBV [2]. Autoantibodies, usually of the IgG subtype, known as antineutrophil cytoplasmic antibodies (ANCAs), are directed against lysosomal components and azurophilic granules found in the cytoplasm of neutrophils and monocytes. The incidence of ANCAs in the general population is thought to be minimal (less than 5%), making them sensitive and specific indicators of ANCA-associated vasculitis [3]. Here, We provide a case of a male patient in his middle age who was diagnosed with c-ANCA-associated small vessel vasculitis secondary to Hepatitis B. Our case involves a rare occurrence of chronic hepatitis associated with c-ANCA-associated vasculitis. It helps us better understand this rare occurrence and enables us to manage it timely.