The pharmacological property of indomethacin, an anti-inflammatory drug approved in 1965, has been lately highlighted for having multiple intermingling pathways, particularly during the COVID-19 epidemic. Originally used as a COX inhibitor and PG regulator. Indomethacin has been found to be effective in many other therapeutic areas. It is a promising anti-cancer and antiviral agent, a central nervous system (CNS) drug, and also useful in treating tuberculosis, tocolysis, aortic rupture, autophagy, and burning scrotum syndrome. Indomethacin’s multifaceted effects are likely the result of its synergistic and reparative modes of action, making it a versatile drug for various medical indications. Currently, much work is being done to develop various formulation approaches for indomethacin to enhance its efficacy while minimizing side effects. Wider exploration of indomethacin in these lesser-known capacities has profound implications in the management of several diseases. The purpose of this review is to catalog the less well-known medicinal roles of indomethacin and compile a succinct overview for researchers. This synthesis of literature could guide future research and contribute to discussions on additional ways indomethacin might be used, ultimately leading to improved medical approaches in various areas. The evolving role of indomethacin in medicine underscores its significance as a ”miracle drug” with many implications.