Factors associated with the presence of post-acute sequelae of
SARS-CoV-2 infection (PASC).
Abstract
Background SARS-CoV-2 is a single-stranded RNA betacoronavirus
capable of evading host immune action allowing replication and tissue
damage. Subsequent symptoms of greater than or equal to 3 months
duration are collectively termed ”post-acute sequelae of SARS-CoV-2
infection” (PASC), which is a multi-organ disorder. Methods
With the aim of determining the factors associated with the presence of
PASC, an analytical study was designed. A total of 404 patients were
evaluated after SARS-Cov-2 infection in consultations to determine which
factors are associated with the presence of PASC (105 met PASC criteria
vs 299).The period of study was from September 2020 to March 2022 at the
Hospital “Clínico Universitario Virgen de la Arrixaca” (HCUVA) in
Murcia. Findings In our study, statistically significant
associations with PASC were found with women, lower mean age, absence of
hypertension, absence of vaccination against SARS-CoV-2, a more
favourable Charlson index, hospital admission during acute infection,
less impact on the Brixia and WHO scale. The multivariate analysis,
showed that female sex, the absence of arterial hypertension and
vaccination, and belonging to WHO group 3, are associated with the
presence of PASC. The highest ROC curves were smoking, female gender and
the Brixia scale.