Background SARS-CoV-2 is a single-stranded RNA betacoronavirus capable of evading host immune action allowing replication and tissue damage. Subsequent symptoms of greater than or equal to 3 months duration are collectively termed ”post-acute sequelae of SARS-CoV-2 infection” (PASC), which is a multi-organ disorder. Methods With the aim of determining the factors associated with the presence of PASC, an analytical study was designed. A total of 404 patients were evaluated after SARS-Cov-2 infection in consultations to determine which factors are associated with the presence of PASC (105 met PASC criteria vs 299).The period of study was from September 2020 to March 2022 at the Hospital “Clínico Universitario Virgen de la Arrixaca” (HCUVA) in Murcia. Findings In our study, statistically significant associations with PASC were found with women, lower mean age, absence of hypertension, absence of vaccination against SARS-CoV-2, a more favourable Charlson index, hospital admission during acute infection, less impact on the Brixia and WHO scale. The multivariate analysis, showed that female sex, the absence of arterial hypertension and vaccination, and belonging to WHO group 3, are associated with the presence of PASC. The highest ROC curves were smoking, female gender and the Brixia scale.