1.1 Study Population
Between July 2021 and July 2023, a cohort comprising 150 patients
diagnosed with non–acute coronary syndrome angina, admitted to the
Cardiology Department of our institution, was prospectively enrolled.
All participants underwent invasive coronary angiography followed by PCI
for coronary artery occlusion. Patients had a history of angina, normal
ECG and cardiac biomarkers, confirmed non-significant plaque rupture via
coronary angiography, stable symptom progression, and comprehensive
clinical assessment to exclude acute coronary syndrome (ACS).Subsequent
to PCI, routine and three-dimensional echocardiography examinations were
conducted on the study cohort at 1 week, 6 months, and 12 months
post-intervention, respectively. Exclusion criteria encompassed
non-sinus rhythm, severe valvular heart disease, acute or previous
myocardial infarction, pulmonary arterial hypertension, suboptimal
echocardiographic image quality, and concurrent malignancies.
Concurrently, a control group comprising 110 gender- and age-matched
individuals undergoing routine health assessments, devoid of
cardiovascular or systemic pathologies, was recruited. Ultrasonographers
analyzing the data remained blinded to the clinical profiles of the
participants.
Prior to enrollment, all subjects provided written informed consent, and
the study protocol received approval from the Institutional Review Board
of our institution.