Aims: This study aimed to examine the relationship between resilience and hope levels of healthcare workers who have experienced the COVID-19 pandemic, the effects of resilience and gender on individual performance, the effects of hope levels on individual performance, and determined whether hope mediated the effect of resilience on individual performance. Design: This was a descriptive cross-sectional study Methods: The Psychological resilience, hopes, and individual performance of health workers affiliated with the Istanbul Provincial Health Directorate were obtained from online questionnaires completed by participants between April 2021 and August 2021. A hierarchical regression analysis, mediation analysis, and moderation analysis were performed on 412 healthcare workers to test the hypotheses. Results: There was a significant relationship between resilience and hope levels among healthcare professionals. In addition, healthcare professionals’ psychological resilience and hope levels significantly affected their performance. The indirect effect of healthcare professionals’ psychological resilience levels on their individual performance through hope was not significant. Conclusion: The findings show that employees with high hope and resilience are more likely to recover from stressful situations and display better individual performance. Impact: This study offers both a practical and theoretical perspective on the effects of hope and resilience on employee performance, as psychological capital that can help all health managers and employees, especially during crisis periods such as the COVID-19 pandemic. The hope and resilience of the employees who use their personal resources as a buffer to cope with the difficult work routine of the employees also increase; thus, difficult work means more resources in the management and, as a result, improves performance. Patient or Public Contribution: No patient or public contribution.