Definitions
SOS diagnosis and grading were based on the European Society for Blood
and Marrow Transplantation (EBMT) Pediatric Criteria (8). AKI was
defined and staged according to Kidney Disease Improving Global Outcomes
(KDIGO) guidelines (9). AKI was classified as severe if it was stage 2
or 3 per KDIGO classification. Fluid overload was calculated according
to the formula described by Goldstein et al.: FO % = Fluid in − fluid
out (L) / intensive care admission body weight in kg × 100 (10).
Cumulative fluid overload is the sum of daily FO % before or after
CKRT. For example, cumulative FO D-3 = (FO% D-3 + FO%D-2 + FO% D-1).
All patients were challenged with diuretics if they did not have
adequate urine output after stopping CKRT. Successful liberation was
defined as patients who did not require CKRT or other dialysis modality
for at least 72 h after discontinuation of CKRT.