Survival
The overall ICU survival rate was 62%, with a 56% rate in the 9 children requiring both IMV and vasopressor support. The duration of the CKRT course and IMV treatment in survivors and non-survivors was similar (Table 1). Non-survivors had a significantly higher serum bilirubin level on D2 (4.7 mg/dL in survivors versus 11mg/dL in non-survivors, p=0.07) and on D3 following CKRT initiation (2.6 mg/dL in survivors vs 14.6 mg/dL in non-survivors, p=0.05) (Figure 2). Survival was not associated with serum levels of albumin, ammonia, prothrombin time, or CRP.
Prior to CKRT initiation, severe AKI was present in all survivors but only 40% of non-survivors (p=0.035). In addition, urine output was higher in non-survivors before CKRT initiation. On D-2 and D-1, respective median urine output was 0.4 and 0.4 ml/kg/h in survivors but 1.4 and 1.6 ml/kg/h in non-survivors (p=0.09 on D-1 and D-2.