Results
Of the 53 children who were critically ill post HCT and received CKRT,
13 had severe SOS and were included in this study. The median age was 6
years, and 62% were males. Most (77%) had allogeneic HCT, with 54%
being past their second transplant. All patients had severe SOS and were
treated with defibrotide except one patient who had severe pulmonary
hemorrhage. In our cohort, 10 patients were intubated and received IMV;
2 received non-invasive positive pressure ventilation, and only one
patient did not require positive pressure ventilation. Most required
vasopressor support (85%), 9 (69%) were on vasopressor support before
the initiation of CKRT. In our cohort, 69% received 3 organs support
(IMV, vasopressors, and CKRT). Prior to CKRT initiation, AKI stage 3 was
present in 77% of our cohort (Table 1). The timeline of the clinical
course of all patients is depicted in Figure 1.