Results
Of the 53 children who were critically ill post HCT and received CKRT, 13 had severe SOS and were included in this study. The median age was 6 years, and 62% were males. Most (77%) had allogeneic HCT, with 54% being past their second transplant. All patients had severe SOS and were treated with defibrotide except one patient who had severe pulmonary hemorrhage. In our cohort, 10 patients were intubated and received IMV; 2 received non-invasive positive pressure ventilation, and only one patient did not require positive pressure ventilation. Most required vasopressor support (85%), 9 (69%) were on vasopressor support before the initiation of CKRT. In our cohort, 69% received 3 organs support (IMV, vasopressors, and CKRT). Prior to CKRT initiation, AKI stage 3 was present in 77% of our cohort (Table 1). The timeline of the clinical course of all patients is depicted in Figure 1.