4. Conclusions
The case described herein illustrates the challenges of diagnosing
lymphoma antemortem in the horse. It suggests that lymphoma should be
included in the differential diagnosis for a horse presenting with
ataxia and neurologic deficits. This case further illustrates the
importance of performing histology in addition to the gross post-mortem
examination. Had histology not been pursued in this case, the
multicentric round cell sarcoma with extensive epidural involvement
would have been missed as the gross lesions were very subtle and not
suggestive of neoplasia at the time of examination. Further testing with
immunohistochemistry phenotyping confirmed the diagnosis of multicentric
diffuse large B cell lymphosarcoma.
Authors’ declaration of interests
No conflicts of interest have been declared.
Ethical animal research
No experimental animals were used in this case report.
Source of funding
None
Acknowledgements
None
Authorship All the authors participated in the article preparation and
have approved the final version.
References
de Lahunta, A. and Glass, E. (2009) Large animal spinal cord disease.In:
Veterinary Neuroanatomy and Clinical Neurology, Eds: A. deLahunta, and
E. Glass, St. Louis, MO: Elsevier. pp 285–318
Durham, A.C., Pillitteri, C.A., San Myint, M. and Valli, V.E. (2013) Two
hundred three cases of equine lymphoma classified according to the World
Health Organization (WHO) classification criteria. Vet. Pathol. 50 , 86–93.
Finding, E.J.T., Ciasca, T., Pinilla, M.J., Driver, C.J., Johns, I.C.,
Weller, R. and Volk, H.A. (2014) Diagnosis, treatment and outcome of
spinal lymphoma in a pony. Equine Veterinary Education 26 , 303–305.
Hirsch, J.E., Grant, B.D., Linovitz, R., Peppers, T.A. and Rantanen,
N.W. (2009) Diagnosis and surgical treatment of epidural neoplasms in
two ataxic horses. Equine Veterinary Education 21 ,
564–568.
Knowles, E.J., Tremaine, W.H., Pearson, G.R. and Mair, T.S. (2016) A
database survey of equine tumours in the United Kingdom. Equine
Vet. J. 48 , 280–284.
Mayhew, I. G., deLahunta, A., Whitlock, R. H., Krook, L. and Tasker,
J.B.(1978) Spinal cord disease in the horse. Cornell Vet. 68, 1–207.
Meyer, J., DeLay, J. and Bienzle, D. (2006) Clinical, Laboratory, and
Histopathologic Features of Equine Lymphoma. Vet. Pathol. 43 , 914–924.
Morrison, L.R., Freel, K., Henderson, I., Hahn, C. and Smith, S.H.
(2008) Lymphoproliferative Disease with Features of Lymphoma in the
Central Nervous System of a Horse. J. Comp. Pathol. 139 ,
256.
Muñoz, A., Riber, C., Trigo, P. and Castejón, F. (2009) Hematopoietic
neoplasias in horses: myeloproliferative and lymphoproliferative
disorders. Journal of Equine Science 20 , 59–72.
Savage, C.J. (1998) Lymphoproliferative and myeloproliferative
disorders. Veterinary Clinics of North America, Equine Practice 14 , 563–578.
Schneider, D.A. (2003) Lymphoproliferative and Myeloproliferative
Disorders. Editor(s): N. Edward Robinson, Current Therapy in Equine
Medicine (Fifth Edition), W.B. Saunders, 2003, Pages 359-362.
Sheard, L. and McGovern, K. (2021) Equine lymphoma: a review.UK-Vet Equine 5 , 206–214.
Taintor, J. and Schleis, S. (2011) Equine lymphoma. Equine
Veterinary Education 23 , 205–213.