2.2 | Definitions of respiratory viral infections and
transplant outcomes
RVIs were classified into high-risk and low-risk RVIs based on the
observed likelihood of risk for complications and type of RVI in prior
studies. High-risk RVIs were adenovirus, HMPV, influenza A and B,
parainfluenza, and RSV. Low-risk RVIs were coronaviruses and
rhinovirus.13-14, 4 Symptoms of RVI were identified as
upper- or lower-respiratory symptoms. Upper-respiratory (UR) symptoms
included congestion, sneezing, headaches, sore throat, and mild cough.
Lower-respiratory symptoms included phlegm, wheezing, chest pain,
serious cough, shortness of breath, and severe cough.
Transplant-related complications were recorded in order to evaluate the
outcome of RVIs on these. These transplant-related complications were
the incidence of graft versus host disease (GVHD) and its grade,
transfer to the intensive care unit (ICU), need for positive pressure
(PP), intubation, bronchoalveolar lavage (BAL), transplant-associated
thrombotic microangiopathy (TA-TMA), adenoviremia, and mortality at day
100 post-transplant.