3.2 | Patterns of RVI and post-transplant outcomes
Of the 161, 34 tested positive for RVs (26 low-risk, 8high-risk). Outcomes were initially analyzed separately by low-risk and high-risk viruses, but given the small number of high-risk patients, statistical analysis was also performed by looking at all positive RVIs as one group. There were too few patients with RV symptoms to analyze independently from those without symptoms. Table 1 displays the number of patients with each characteristic as described previously by RVI negative and RVI positive groups, compared to the overall number of subjects in the study.
Within the first 100 days post-transplant, a positive pre-HSCT RVI was significantly associated with increased mortality (odds ratio (OR) = 6.56, p = 0.04 after adjusting for multiple testing) (Fig. 1) and requirement for ICU transfer (OR = 3.75, p = 0.005). All other outcomes did not differ significantly based on pre-HSCT RV PCR positivity. In a sensitivity analysis, the statistical significance of the two associations did not change when potential confounding covariates were included in analyses. (Table 2)