3.2 | Patterns of RVI and post-transplant outcomes
Of the 161, 34 tested positive for RVs (26 low-risk, 8high-risk).
Outcomes were initially analyzed separately by low-risk and high-risk
viruses, but given the small number of high-risk patients, statistical
analysis was also performed by looking at all positive RVIs as one
group. There were too few patients with RV symptoms to analyze
independently from those without symptoms. Table 1 displays the number
of patients with each characteristic as described previously by RVI
negative and RVI positive groups, compared to the overall number of
subjects in the study.
Within the first 100 days post-transplant, a positive pre-HSCT RVI was
significantly associated with increased mortality (odds ratio (OR) =
6.56, p = 0.04 after adjusting for multiple testing) (Fig. 1) and
requirement for ICU transfer (OR = 3.75, p = 0.005). All other outcomes
did not differ significantly based on pre-HSCT RV PCR positivity. In a
sensitivity analysis, the statistical significance of the two
associations did not change when potential confounding covariates were
included in analyses. (Table 2)