Treatment with deep brain stimulation (DBS)
The participants were randomized to DBS in either MFB or BNST for the
first three months, followed by a crossover to the opposite target area
for three months, with patients and raters blinded to the DBS target.
Following the blinded phase, the patients entered an open-label phase
and received continuous stimulation in the most optimal targets. For the
stimulation target and parameters, see Supplement Table 1.