4. Discussion
In the current study, we assessed region-specific distribution of the
CB1Rs across the central auditory system of mice using fluorescence
immunohistochemical techniques. Our results revealed that CB1Rs are
highly expressed in the CN, SOC and LL. Furthermore, the conditional
knockout of CB1Rs specifically from PV interneurons resulted in hearing
loss and abnormal auditory brainstem response to a certain extent. Our
findings support a functional role for CB1Rs in regulating inhibitory
circuitry function in the central auditory system, ultimately impacting
auditory processing.