IntroductionThe CRYAB gene encodes the protein Alpha-B-crystallin, or αB-crystallin, a protein belonging to the small heat shock family of proteins that has been linked to normal cardiac homeostasis as well as cardiomyopathies, among other diseases 1. CRYAB, the causal gene, is 3.2 kilobases long and situated on chromosome 11 2. Although its role as a molecular chaperone for desmin is well established, it also engages in interactions with a diverse range of other proteins 1.Mutations in the CRYAB gene have been associated with congenital cataracts, myopathies, neurodegenerative diseases, and besides with hypertrophic cardiomyopathy (HCM), and less commonly with dilated cardiomyopathy (DCM) and restrictive cardiomyopathy (RCM)1,3-5.However, the CRYAB association with DCM has recently emerged in the last decade, which is why it may not be included in the list of genetic mutations associated with DCM according to the most recent guidelines of the European Society of Cardiology (ESC) and some reviews in recent literature. However, increasing emerging observational evidence suggests an association with DCM. Below we describe the case of a patient who developed DCM whit restrictive physiology secondary to a heterozygous mutation of the CRYAB gene.