Reference
Allan, K. J., Biggs, H. M., Halliday, J. E. B., & Kazwala, R. R. (2015). Epidemiology of
Leptospirosis in Africa: A Systematic Review of a Neglected Zoonosis and a Paradigm for One Health in Africa . 1–25. https://doi.org/10.1371/journal.pntd.0003899
Assenga, J. A., Matemba, L. E., Muller, S. K., Mhamphi, G. G., & Kazwala, R. R. (2015).
Predominant Leptospiral Serogroups Circulating among Humans, Livestock and Wildlife in Katavi-Rukwa Ecosystem, Tanzania. PLoS Neglected Tropical Diseases , 9(3 ), 1–14. https://doi.org/10.1371/journal.pntd.0003607
Boey, K., Shiokawa, K., & Rajeev, S. (2019). Leptospira infection in rats: A literature review of global prevalence and distribution.PLoS Neglected Tropical Diseases, 1 3(8), 1–24. https://doi.org/10.1371/journal.pntd.0007499
Costa, F., Hagan, J. E., Calcagno, J., Kane, M., Torgerson, P., Martinez-silveira, M. S., Stein,C., Abela-ridder, B., & Ko, A. I. (2015). Global Morbidity and Mortality of Leptospirosis: Systematic Review . 0–1 https://doi.org/10.1371/journal.pntd.0003898
Ellis, W. A. (2015). Animal Leptospirosis. In Current Topics in Microbiology and Immunology (Vol. 387). https://doi.org/10.1007/978-3-662-45059-8_6
Hashemi, S. A., Arzamani, K., Abdollahpour, G., Beheshti, N., Alavinia, M., Azimian, A., Neela, V. K., van Belkum, A., & Ghasemzadeh-moghaddam, H. (2021). Seroprevalence of Leptospira infection in occupational risk groups in North Khorasan province, Iran.Heliyon ,7(1),e05983. https://doi.org/10.1016/j.heliyon.2021.e05983
Katakweba, A. A. S., Mulungu, L. S., Eiseb, S. J., Mahlaba, T. A., Makundi, R. H., Massawe, A. W., Borremans, B., & Belmain, S. R. (2012). Prevalence of haemoparasites, leptospires, and coccobacilli with potential for human infection in the blood of rodents and shrews from selected localities in Tanzania, Namibia, and Swaziland. African Zoology , 47(1), 119–127. https://doi.org/10.3377/004.047.0112
Majawa, C. A., Lupindu, A. M., Mhamphi, G. G., Robert, S., & Katakweba, A. A. S. (n.d.).
Seroprevalence of Leptospira antibodies in rodents and shrews of Kibondo and Kakonko Districts, Kigoma region, Tanzania . 16, 55–74.
Masunga, D. S., Rai, A., Abbass, M., Uwishema, O., Wellington, J., Uweis, L., El Saleh, R., Arab, S., Onyeaka, C. V. P., & Onyeaka, H. (2022). Leptospirosis outbreak in Tanzania: An alarming situation.Annals of Medicine and Surgery, 80 (July).
https://doi.org/10.1016/j.amsu.2022.104347
Maze, M. J., Shirima, G. M., Lukambagire, A. H. S., Bodenham, R. F., Rubach, M. P., Cash- Goldwasser, S., Carugati, M., Thomas, K. M., Sakasaka, P., Mkenda, N., Allan, K. J., Kazwala, R. R., Mmbaga, B. T., Buza, J. J., Maro, V. P., Galloway, R. L., Haydon, D. T., Crump, J. A., & Halliday, J. E. B. (2023). Prevalence and risk factors for human leptospirosis at a hospital serving a pastoralist community, Endulen, Tanzania. PLoS Neglected Tropical Diseases , 17(12), 1–15. https://doi.org/10.1371/journal.pntd.0011855
Mgode, G. F., Japhary, M. M., Mhamphi, G. G., Kiwelu, I., Athaide, I., & Machang’u, R. S. (2019). Leptospirosis in sugarcane plantation and fishing communities in Kagera northwestern Tanzania. PLoS Neglected Tropical Diseases , 13(5), 1–12. https://doi.org/10.1371/journal.pntd.0007225
Mgode, G. F., Mhamphi, G. G., Massawe, A. W., & Machang’u, R. S. (2021). Leptospira
Seropositivity in humans, livestock, and wild animals in a semi-arid area of Tanzania.
Pathogens , 10(6), 1–12. https://doi.org/10.3390/pathogens10060696
Mlowe, G. D., Makundi, I., Katakweba, A. S., & Machang, R. (2023).Seropositivity of Leptospira in rodents, shrews, and domestic animals in Unguja, Tanzania. 6, 878–886.
Motto, S. K., Hernandez-Castro, L. E., Shirima, G. M., Mengele, I. J., Bwatota, S. F.,
Bronsvoort, B. M. de C., Lyatuu, E. T., Komwihangilo, D. M., & Cook, E. A. J. (2023).
Seroepidemiology of Leptospira serovar Hardjo and associated risk factors in smallholder dairy cattle in Tanzania. PLoS Neglected Tropical Diseases, 17 (4). https://doi.org/10.1371/journal.pntd.0011199
Motto, S. K., Shirima, G. M., de Clare Bronsvoort, B. M., & Cook, E. A. J. (2021). Epidemiology of leptospirosis in Tanzania: A review of the current status, serogroup diversity and reservoirs. PLoS Neglected Tropical Diseases, 15(1 1). https://doi.org/10.1371/journal.pntd.0009918
Msemwa, B., Mirambo, M. M., Silago, V., Samson, J. M., Majid, K. S., Mhamphi, G.,
Genchwere, J., Mwakabumbe, S. S., Mngumi, E. B., Mgode, G., & Mshana, S. E. (2021). Existence of Similar Leptospira Serovars among Dog Keepers and Their Respective Dogs in Mwanza, Tanzania, the Need for a One Health Approach to Control Measures.
Ngugi, J. N., Fèvre, E. M., Mgode, G. F., Obonyo, M., Mhamphi, G. G., Otieno, C. A., Anne, E., & Cook, J. (2019). Seroprevalence and associated risk factors of leptospirosis in slaughter pigs; a neglected public health risk, western Kenya . 1–11.
Niloofa, R., Fernando, N., De Silva, N. L., Karunanayake, L., Wickramasinghe, H.,
Dikmadugoda, N., Premawansa, G., Wickramasinghe, R., De Silva, H. J Premawansa, S., Rajapakse, S., & Handunnetti, S. (2015). Diagnosis of leptospirosis: Comparison between microscopic agglutination test, IgM-ELISA, and IgM rapid immunochromatography test. PLoS ONE, 10(6), 1–12. https://doi.org/10.1371/journal.pone.0129236
Nthiwa, D., Alonso, S., Odongo, D., Kenya, E., & Bett, B. (2019). Zoonotic Pathogen
Seroprevalence in Cattle in a Wildlife–Livestock Interface, Kenya.EcoHealth , 16(4), 712–725. https://doi.org/10.1007/s10393-019-01453-z
Schoonman, L., & Swai, E. S. (2009). Risk factors associated with the seroprevalence of
Leptospirosis, amongst at-risk groups in and around Tanga city, Tanzania. Annals of
Tropical Medicine and Parasitology, 103(8), 711–718.
https://doi.org/10.1179/000349809X12554106963393
Soares, P. M., Gomes, D. O., Macedo, F. P., Soares, M. M., Lemes, K. R., Jaeger, L. H.,
Lilenbaum, W., & Lima, A. M. C. (2020). Serological and molecular characterization of Leptospira Kirschner serogroup Grippotyphosa isolated from bovine in Brazil. Microbial Pathogenesis , 138(September 2019), 103803. https://doi.org/10.1016/j.micpath.2019.103803
Swai, E. S., & Schoonman, L. (2012a). A survey of zoonotic diseases in trade cattle slaughtered at Tanga city abattoir: A cause of public health concern. Asian Pacific Journal of Tropical Biomedicine, 2(1), 55–60. https://doi.org/10.1016/S2221-1691(11)60190-1
The United Republic of Tanzania (URT). (2022). Ministry of Finance and Planning, Tanzania National Bureau of Statistics and President’s Office - Finance and Planning, Office of the Chief Government Statistician, Zanzibar. The Population and Housing Census: Administrative Units Population Distribution. 54.
Torgerson, P. R., Hagan, J. E., Costa, F., Calcagno, J., Kane, M., Martinez-silveira, M. S., Goris, M. G. A., Stein, C., & Ko, A. I. (2015). Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years . 1–14. https://doi.org/10.1371/journal.pntd.0004122
Vijayachari, P., Sugunan, A. P., & Shriram, A. N. (2008). Leptospirosis: An emerging public health problem. Journal of Biosciences, 33(4), 557–569.
https://doi.org/10.1007/s12038-008-0074-z
Figure 1. Map of Muheza districts, Tanga region, Tanzania showing the study sites
Reference: QGIS. 3.34.1-Prizren; EPSG: 4326- WGS 84.
Figure 2. Co-infection with different leptospiral serovars in rodents, humans, and cattle
Table 1. Rodents’ species captured and their seroprevalence of leptospiral antibodies in various species of rodents in the Tanga region, Tanzania (n=201)
Table 2. Sero-prevalence of Leptospira antibodies in cattle in the study area (n= 80)
Table 3. Number and percentage of study subjects found seropositive to Leptospira bacteria with socio-demographics information of the study participants (n=198)
Table 4. Seroprevalence of different leptospiral serovars in rodents, humans, and cattle in the Tanga region, Tanzania.
Table 5. Logistic Regression to assess the association of seroprevalence of Leptospira antibodies in humans, rodents, and cattle to different variables