not-yet-known not-yet-known not-yet-known unknown Fig.5. Potential mechanisms and key injury molecules in SI-ALI. Gene Ontology (GO) Term Analysis of DEPs related to SI-ALI in the lung chip model, categorized into Biological Process (BP), Cellular Component (CC), and Molecular Function (MF). Schematic of the KEGG Pathway Analysis for DEPs associated with SI-ALI in the lung chip model. Venn diagram delineating the DEPs exclusive to the chip model (blue circle), the animal model (yellow circle), and their intersection (green portion), with gene names of the overlapping DEPs presented in a green rectangle. Red denotes upregulated proteins, while blue signifies downregulated ones. List of notable molecules correlated with SI-ALI, encompassing DOCK2, TST, KRR1, NIT1, RAP1GDS1, and COMT.