Fig.4. Immune responses associated with smoke-induced lung
injury in the chip model.
Comparative expression levels of inflammation and apoptosis-associated
genes in the epithelial or endothelial layers of the chip with versus
without smoke stimulation were assessed. Three independent assays were
conducted on the chip; findings are presented as mean ± standard
deviation (SD). n=3.
Quantification of IL-1β, IL-6, and TNF-α secretion from the
endothelial layer of the chip after smoke exposure, with or without
THP-1 cell interaction. The results are based on three separate
experiments and expressed as mean ± standard deviation (SD). n=9.