Our study reveals the potential distribution and future migration trends of four Lamiaceae alpine species endemic to the Third Pole region. Temperature, closely following precipitation, is the dominant ecological factor shaping their distribution. Their potential distribution areas have experienced a contraction from the LGM to the present. In the future, climate change will transform TP into a suitable destination for species migration. However, limited dispersal abilities and reconstruction of biological interactions will restrict alpine species to fully track climatic changes. Alpine species still confront severe climate risks and adverse impacts from harvesting, rendering their prospects uncertain. Protecting the stable and suitable areas at the summits of the HHM is crucial for ensuring the survival of alpine species amidst climate change.